IQGAP2 (IQ motif containing GTPase activating protein 2)

2003-11-01  

Identity

HGNC
LOCATION
5q13.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10788
MIM: 605401
HGNC: 6111
Ensembl: ENSG00000145703

Variants:

dbSNP: 10788
ClinVar: 10788
TCGA: ENSG00000145703
COSMIC: IQGAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145703ENST00000274364Q13576
ENSG00000145703ENST00000379730F5H7S7
ENSG00000145703ENST00000396234Q13576
ENSG00000145703ENST00000502745Q13576
ENSG00000145703ENST00000504254D6R999
ENSG00000145703ENST00000504477H0YA28
ENSG00000145703ENST00000505766E7EWC2
ENSG00000145703ENST00000509074D6RDK8
ENSG00000145703ENST00000513534D6RGC6
ENSG00000145703ENST00000514001E9PDT6
ENSG00000145703ENST00000514350D6R939

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate IQGAPsREACTOMER-HSA-5626467
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375045712023Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle.1
375045712023Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle.1
338463022021Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status.17
340347072021IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.6
338463022021Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status.17
340347072021IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.6
321830472020IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.15
322503922020Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren's syndrome.13
321830472020IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.15
322503922020Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren's syndrome.13
293583232018Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.28
293583232018Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.28
290731992017Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.20
290731992017Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.20
261877382016The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population.3

Citation

Dessen P

IQGAP2 (IQ motif containing GTPase activating protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40988/iqgap2