IRF2 (interferon regulatory factor 2)

2003-05-01  

Identity

HGNC
IRF2
LOCATION
4q35.1
LOCUSID
3660
ALIAS
IRF-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3660
MIM: 147576
HGNC: 6117
Ensembl: ENSG00000168310

Variants:

dbSNP: 3660
ClinVar: 3660
TCGA: ENSG00000168310
COSMIC: IRF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168310ENST00000393593P14316
ENSG00000168310ENST00000502750H0Y956
ENSG00000168310ENST00000505067K4DIA4
ENSG00000168310ENST00000506230D6R9N5
ENSG00000168310ENST00000507523K4DIA5
ENSG00000168310ENST00000509274D6RED1
ENSG00000168310ENST00000510814D6RB08

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365210022023Interferon regulatory factor-2 is required for the establishment of the gut intraepithelial T-cell compartment.0
365210022023Interferon regulatory factor-2 is required for the establishment of the gut intraepithelial T-cell compartment.0
351150272022IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer.3
365447622022IRF2 is required for development and functional maturation of human NK cells.2
351150272022IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer.3
365447622022IRF2 is required for development and functional maturation of human NK cells.2
341854192021IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA.13
349303592021IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3.3
341854192021IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA.13
349303592021IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3.3
313507072020IRF-2 Inhibits Gastric Cancer Invasion and Migration by Down-Regulating MMP-1.13
319682182020Exosomes derived from human bone marrow mesenchymal stem cells transfer miR-222-3p to suppress acute myeloid leukemia cell proliferation by targeting IRF2/INPP4B.33
321157372020IRF2-INPP4B axis inhibits apoptosis of acute myeloid leukaemia cells via regulating T helper 1/2 cell differentiation.1
322714312020ELF1 activated long non-coding RNA CASC2 inhibits cisplatin resistance of non-small cell lung cancer via the miR-18a/IRF-2 signaling pathway.12
323778172020Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells.49

Citation

Dessen P

IRF2 (interferon regulatory factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40991