IRF5 (interferon regulatory factor 5)

2003-05-01  

Identity

HGNC
IRF5
LOCATION
7q32.1
LOCUSID
3663
ALIAS
SLEB10

Other Information

Locus ID:

NCBI: 3663
MIM: 607218
HGNC: 6120
Ensembl: ENSG00000128604

Variants:

dbSNP: 3663
ClinVar: 3663
TCGA: ENSG00000128604
COSMIC: IRF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128604ENST00000249375Q13568
ENSG00000128604ENST00000357234Q13568
ENSG00000128604ENST00000357234C9JAU6
ENSG00000128604ENST00000402030Q13568
ENSG00000128604ENST00000464557C9JYP7
ENSG00000128604ENST00000465603Q13568
ENSG00000128604ENST00000467002C9JB67
ENSG00000128604ENST00000473745Q13568
ENSG00000128604ENST00000473787F8WDH6
ENSG00000128604ENST00000477535Q13568
ENSG00000128604ENST00000479582C9J7M2
ENSG00000128604ENST00000489702Q13568
ENSG00000128604ENST00000489702C9JAU6
ENSG00000128604ENST00000613821A0A087WWA0
ENSG00000128604ENST00000619830Q13568
ENSG00000128604ENST00000652525A0A0G2UM11

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381418652024Role of interferon regulatory factor 5 (IRF5) in tumor progression: Prognostic and therapeutic potential.1
381757092024IRF5 governs macrophage adventitial infiltration to fuel abdominal aortic aneurysm formation.0
387452652024M6A-induced transcription factor IRF5 contributes to the progression of cervical cancer by upregulating PPP6C.0
381418652024Role of interferon regulatory factor 5 (IRF5) in tumor progression: Prognostic and therapeutic potential.1
381757092024IRF5 governs macrophage adventitial infiltration to fuel abdominal aortic aneurysm formation.0
387452652024M6A-induced transcription factor IRF5 contributes to the progression of cervical cancer by upregulating PPP6C.0
362452802023Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.4
365290292023Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection.0
367820482023Cytoplasmic localization of IRF5 induces Wnt5a/E-cadherin degradation and promotes gastric cancer cells metastasis.1
368690522023An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.7
372547912023IRF5-TNOP3 polymorphisms are associated with elite control of HIV infection: A retrospective study.0
375948492023IRF5 promotes glycolysis in the progression of hepatocellular carcinoma and is regulated by TRIM35.1
362452802023Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.4
365290292023Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection.0
367820482023Cytoplasmic localization of IRF5 induces Wnt5a/E-cadherin degradation and promotes gastric cancer cells metastasis.1

Citation

Dessen P

IRF5 (interferon regulatory factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40992