ITGA3 (integrin subunit alpha 3)

2003-05-01  

Identity

HGNC
ITGA3
LOCATION
17q21.33
LOCUSID
3675
ALIAS
CD49C,FRP-2,GAP-B3,GAPB3,ILNEB,MSK18,VCA-2,VL3A,VLA3a
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3675
MIM: 605025
HGNC: 6139
Ensembl: ENSG00000005884

Variants:

dbSNP: 3675
ClinVar: 3675
TCGA: ENSG00000005884
COSMIC: ITGA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005884ENST00000007722P26006
ENSG00000005884ENST00000320031P26006
ENSG00000005884ENST00000320031A0A140VJM0
ENSG00000005884ENST00000504417K7EQJ2
ENSG00000005884ENST00000506401D6R9X8
ENSG00000005884ENST00000506827H0YA49
ENSG00000005884ENST00000510809H0YA32
ENSG00000005884ENST00000512553K7EMU3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Hematopoietic cell lineageKEGGko04640
Regulation of actin cytoskeletonKEGGko04810
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Hematopoietic cell lineageKEGGhsa04640
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Signal TransductionREACTOMER-HSA-162582
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Integrin cell surface interactionsREACTOMER-HSA-216083
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368432582023Integrin α3 Mediates Stemness and Invasion of Glioblastoma by Regulating POU3F2.3
378317592023Integrin α3 promotes T(H)17 cell polarization and extravasation during autoimmune neuroinflammation.1
368432582023Integrin α3 Mediates Stemness and Invasion of Glioblastoma by Regulating POU3F2.3
378317592023Integrin α3 promotes T(H)17 cell polarization and extravasation during autoimmune neuroinflammation.1
359700812022YY1/ITGA3 pathway may affect trophoblastic cells migration and invasion ability.2
359700812022YY1/ITGA3 pathway may affect trophoblastic cells migration and invasion ability.2
337687052021Skin fragility, renal malformation and interstitial lung disease due to compound heterozygous ITGA3 mutations.1
340233632021Homozygous ITGA3 Missense Mutation in Adults in a Family with Syndromic Epidermolysis Bullosa (ILNEB) without Pulmonary Involvement.3
341021692021Detection of bladder cancer with aberrantly fucosylated ITGA3.8
342427482021CD9 and ITGA3 are regulated during HIV-1 infection in macrophages to support viral replication.3
349383582021miRNA-144-5p/ITGA3 Suppressed the Tumor-Promoting Behaviors of Thyroid Cancer Cells by Downregulating ITGA3.4
337687052021Skin fragility, renal malformation and interstitial lung disease due to compound heterozygous ITGA3 mutations.1
340233632021Homozygous ITGA3 Missense Mutation in Adults in a Family with Syndromic Epidermolysis Bullosa (ILNEB) without Pulmonary Involvement.3
341021692021Detection of bladder cancer with aberrantly fucosylated ITGA3.8
342427482021CD9 and ITGA3 are regulated during HIV-1 infection in macrophages to support viral replication.3

Citation

Dessen P

ITGA3 (integrin subunit alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41004