ITGB3 (integrin subunit beta 3)

2003-08-01 Affiliation

Identity

HGNC

ITGB3

LOCATION

17q21.32

LOCUSID

3690

ALIAS

BDPLT16,BDPLT2,BDPLT24,CD61,GP3A,GPIIIa,GT,GT2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3690
MIM: 173470
HGNC: 6156
Ensembl: ENSG00000259207

Variants:

dbSNP: 3690
ClinVar: 3690
TCGA: ENSG00000259207
COSMIC: ITGB3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000259207	ENST00000559488	P05106
ENSG00000259207	ENST00000571680	I3L4X8
ENSG00000259207	ENST00000573377	Q16157

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Focal adhesion	KEGG	ko04510
ECM-receptor interaction	KEGG	ko04512
Hematopoietic cell lineage	KEGG	ko04640
Regulation of actin cytoskeleton	KEGG	ko04810
Focal adhesion	KEGG	hsa04510
ECM-receptor interaction	KEGG	hsa04512
Hematopoietic cell lineage	KEGG	hsa04640
Regulation of actin cytoskeleton	KEGG	hsa04810
Hypertrophic cardiomyopathy (HCM)	KEGG	ko05410
Hypertrophic cardiomyopathy (HCM)	KEGG	hsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG	ko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG	hsa05412
Dilated cardiomyopathy	KEGG	ko05414
Dilated cardiomyopathy	KEGG	hsa05414
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Thyroid hormone signaling pathway	KEGG	hsa04919
Platelet activation	KEGG	hsa04611
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
MAP2K and MAPK activation	REACTOME	R-HSA-5674135
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Integrin alphaIIb beta3 signaling	REACTOME	R-HSA-354192
GRB2:SOS provides linkage to MAPK signaling for Integrins	REACTOME	R-HSA-354194
p130Cas linkage to MAPK signaling for integrins	REACTOME	R-HSA-372708
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
PECAM1 interactions	REACTOME	R-HSA-210990
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Extracellular matrix organization	REACTOME	R-HSA-1474244
Elastic fibre formation	REACTOME	R-HSA-1566948
Molecules associated with elastic fibres	REACTOME	R-HSA-2129379
Non-integrin membrane-ECM interactions	REACTOME	R-HSA-3000171
Syndecan interactions	REACTOME	R-HSA-3000170
ECM proteoglycans	REACTOME	R-HSA-3000178
Integrin cell surface interactions	REACTOME	R-HSA-216083
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
L1CAM interactions	REACTOME	R-HSA-373760
Signal transduction by L1	REACTOME	R-HSA-445144
RET signaling	REACTOME	R-HSA-8853659
Oncogenic MAPK signaling	REACTOME	R-HSA-6802957
Signaling by RAS mutants	REACTOME	R-HSA-6802949
Signaling by high-kinase activity BRAF mutants	REACTOME	R-HSA-6802948
Signaling by moderate kinase activity BRAF mutants	REACTOME	R-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAF	REACTOME	R-HSA-6802955
Signaling by BRAF and RAF fusions	REACTOME	R-HSA-6802952
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PD	10459913, 10704169, 11054089, 11723016, 15840736, 16153930, 16458133, 16493486, 16581111, 16675000, 17184645, 20138334, 22028352, 23834376
PA33384	PLCB1	Gene	Pathway	associated		20938371
PA33393	PLCG2	Gene	Pathway	associated		20938371
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated	PD	10459913, 10704169, 11054089, 11723016, 15166949, 15840736, 16153930, 16458133, 16493486, 16581111, 16675000, 17184645, 19106083, 19530321, 20138334, 22028352, 23834376
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation	associated	PD	15166949, 16458133, 19106083, 19530321, 22028352, 23834376
PA448006	abciximab	Chemical	Pathway	associated		20938371
PA448497	aspirin	Chemical	ClinicalAnnotation	associated	PD	10459913, 10704169, 11054089, 11723016, 15840736, 16153930, 16458133, 16493486, 16581111, 16675000, 17184645, 20138334, 22028352, 23834376
PA449053	clopidogrel	Chemical	ClinicalAnnotation	associated	PD	15166949, 16458133, 19106083, 19530321, 22028352, 23834376
PA449483	eptifibatide	Chemical	Pathway	associated		20938371
PA451698	tirofiban	Chemical	Pathway	associated		20938371

References

Pubmed ID	Year	Title	Citations
38081783	2024	The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.	0
38195194	2024	Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure.	1
38561495	2024	Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.	0
38588407	2024	Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.	1
38081783	2024	The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.	0
38195194	2024	Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure.	1
38561495	2024	Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.	0
38588407	2024	Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.	1
36772869	2023	ITGB3 promotes cisplatin resistance in osteosarcoma tumors.	5
36884296	2023	A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia.	0
36937472	2023	Genetic screening of PLA1/PLA2 polymorphous marker of integrin beta 3 (ITGB3) GP IIIA gene in adolescent girls with puberty menorrhagia.	0
37280310	2023	Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3.	2
37716584	2023	Effect of c.1431C > T mutation, a causative mutation of Glanzmann's thrombasthenia, on ITGB3 splicing, gene and protein expression.	0
38009896	2023	Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.	0
36772869	2023	ITGB3 promotes cisplatin resistance in osteosarcoma tumors.	5

Citation

Dessen P

ITGB3 (integrin subunit beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41019/itgb3

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