450 Kb, 11 exons.

Main RNA species with 9Kb. An alternatively spliced variant with 81 additional bp.

Tetramer consisting of subunits with 969 aminoacids each. The protein contains a PAS domain at the N-terminus, "Channel" domain with typical features of K channels (six putatively transmembrane segments and a pore loop between fifth and sixth). Large C-terminal domain with cyclic-nucleotide-binding domain, calmodulin binding site, tetramerizing coiled-coil. The sequence has many potential posttranslational modification sites, but only glycosylation has been reported.

Abundant in many brain regions, virtually absent from extracranial tissues. Detected in gastric gland chief cells, pancreatic acini, spermatogenic cells, endocervix, secretory endometrium, reactive lymph nodes (germinal centre), mast cells, macrophages, anterior pituitary, adrenal gland.

Plasma membrane. Abundant in intracellular pools both in neurons and tumor cells.

Voltage-gated potassium channel.

Homologous to the "six-transmembrane, one pore" potassium channel superfamily.