KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1)

2003-02-01  

Identity

HGNC
LOCATION
1p35.2
LOCUSID
ALIAS
Sam68,p62,p68
FUSION GENES

Other Information

Locus ID:

NCBI: 10657
MIM: 602489
HGNC: 18116
Ensembl: ENSG00000121774

Variants:

dbSNP: 10657
ClinVar: 10657
TCGA: ENSG00000121774
COSMIC: KHDRBS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121774ENST00000327300Q07666
ENSG00000121774ENST00000492989Q07666

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 Regulates Proteins Involved in RNA ProcessingREACTOMER-HSA-8849468

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377922222024Sam68 is a druggable vulnerability point in cancer stem cells.0
386603022024KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity.0
377922222024Sam68 is a druggable vulnerability point in cancer stem cells.0
386603022024KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity.0
352177912022Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51.7
360828072022High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma.0
361393962022Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients.2
363448462022The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer.7
365371902022Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions.5
352177912022Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51.7
360828072022High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma.0
361393962022Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients.2
363448462022The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer.7
365371902022Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions.5
327801502021ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs.5

Citation

Dessen P

KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41056/case-report-explorer/css/lib/haematological-explorer/