Identity
HGNC
LOCATION
1p35.2
LOCUSID
ALIAS
Sam68,p62,p68
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10657
MIM: 602489
HGNC: 18116
Ensembl: ENSG00000121774
Variants:
dbSNP: 10657
ClinVar: 10657
TCGA: ENSG00000121774
COSMIC: KHDRBS1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000121774 | ENST00000327300 | Q07666 |
| ENSG00000121774 | ENST00000492989 | Q07666 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by PTK6 | REACTOME | R-HSA-8848021 |
| PTK6 Regulates Proteins Involved in RNA Processing | REACTOME | R-HSA-8849468 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37792222 | 2024 | Sam68 is a druggable vulnerability point in cancer stem cells. | 0 |
| 38660302 | 2024 | KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity. | 0 |
| 37792222 | 2024 | Sam68 is a druggable vulnerability point in cancer stem cells. | 0 |
| 38660302 | 2024 | KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity. | 0 |
| 35217791 | 2022 | Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51. | 7 |
| 36082807 | 2022 | High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma. | 0 |
| 36139396 | 2022 | Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients. | 2 |
| 36344846 | 2022 | The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer. | 7 |
| 36537190 | 2022 | Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions. | 5 |
| 35217791 | 2022 | Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51. | 7 |
| 36082807 | 2022 | High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma. | 0 |
| 36139396 | 2022 | Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients. | 2 |
| 36344846 | 2022 | The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer. | 7 |
| 36537190 | 2022 | Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions. | 5 |
| 32780150 | 2021 | ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs. | 5 |
Citation
Dessen P
KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41056/khdrbs1
