KLHL21 (kelch like family member 21)

2003-05-01  

Identity

HGNC
LOCATION
1p36.31
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 9903
MIM: 616262
HGNC: 29041
Ensembl: ENSG00000162413

Variants:

dbSNP: 9903
ClinVar: 9903
TCGA: ENSG00000162413
COSMIC: KLHL21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162413ENST00000377658Q9UJP4
ENSG00000162413ENST00000377663Q9UJP4
ENSG00000162413ENST00000463043K7EMF2
ENSG00000162413ENST00000467612K7ELI0
ENSG00000162413ENST00000496707K7ESH2
ENSG00000162413ENST00000610898Q2NKK7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
295741532018Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation.5
295741532018Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation.5
273875022016Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.11
277692512016KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma.22
273875022016Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.11
277692512016KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma.22
199959372009The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.69
199959372009The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.69

Citation

Dessen P

KLHL21 (kelch like family member 21)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41059/favicon/js/lib/zoomerang.js