KLK1 (kallikrein 1)

2003-06-01  

Identity

HGNC
KLK1
LOCATION
19q13.33
LOCUSID
3816
ALIAS
KLKR,Klk6,hK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3816
MIM: 147910
HGNC: 6357
Ensembl: ENSG00000167748

Variants:

dbSNP: 3816
ClinVar: 3816
TCGA: ENSG00000167748
COSMIC: KLK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167748ENST00000301420P06870
ENSG00000167748ENST00000301420A0A1R3UCD2
ENSG00000167748ENST00000593325M0R318

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426

References

Pubmed IDYearTitleCitations
333553642021Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress.2
333978112021Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI.23
333553642021Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress.2
333978112021Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI.23
306184162019Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.7
308019442019Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.16
309089372019Tissue kallikrein regulates alveolar macrophage apoptosis early in influenza virus infection.6
318731762019Associations of ACE I/D polymorphism with the levels of ACE, kallikrein, angiotensin II and interleukin-6 in STEMI patients.23
306184162019Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.7
308019442019Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.16
309089372019Tissue kallikrein regulates alveolar macrophage apoptosis early in influenza virus infection.6
318731762019Associations of ACE I/D polymorphism with the levels of ACE, kallikrein, angiotensin II and interleukin-6 in STEMI patients.23
283220372018Analysis of KLK1 polymorphism (rs5516) in patients with abdominal aortic aneurysm or thoracic aortic dissection.1
283220372018Analysis of KLK1 polymorphism (rs5516) in patients with abdominal aortic aneurysm or thoracic aortic dissection.1
286215572017A positive association between the human tissue kallikerin gene A2233C polymorphism and blood pressure response to benazepril.0

Citation

Dessen P

KLK1 (kallikrein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41075