KPNA2 (karyopherin subunit alpha 2)

2003-05-01  

Identity

HGNC
KPNA2
LOCATION
17q24.2
LOCUSID
3838
ALIAS
IPOA1,QIP2,RCH1,SRP1-alpha,SRP1alpha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3838
MIM: 600685
HGNC: 6395
Ensembl: ENSG00000182481

Variants:

dbSNP: 3838
ClinVar: 3838
TCGA: ENSG00000182481
COSMIC: KPNA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182481ENST00000330459P52292
ENSG00000182481ENST00000537025P52292
ENSG00000182481ENST00000579754J3KS65
ENSG00000182481ENST00000583269J3QL07
ENSG00000182481ENST00000584026J3QLL0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Influenza AKEGGko05164
Influenza AKEGGhsa05164
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Host Interactions with Influenza FactorsREACTOMER-HSA-168253
NS1 Mediated Effects on Host PathwaysREACTOMER-HSA-168276
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Sensing of DNA Double Strand BreaksREACTOMER-HSA-5693548

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367994242024Hsa_Circ_0000021 Sponges miR-3940-3p/KPNA2 Expression to Promote Cervical Cancer Progression.1
382253482024Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells.0
367994242024Hsa_Circ_0000021 Sponges miR-3940-3p/KPNA2 Expression to Promote Cervical Cancer Progression.1
382253482024Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells.0
365393672023Long noncoding RNA TUG1 decreases bladder cancer chemo-sensitivity toward doxorubicin through elevating KPNA2 expression and activating the PI3K/AKT pathway via adsorbing miR-582-5p.2
365834842023MiR-101-3p targets KPNA2 to inhibit the progression of lung squamous cell carcinoma cell lines.2
371211482023Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma.1
374239522023ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling.1
382833602023Mutational analysis of SARS-CoV-2 ORF6-KPNA2 binding interface and identification of potent small molecule inhibitors to recuse the host immune system.0
365393672023Long noncoding RNA TUG1 decreases bladder cancer chemo-sensitivity toward doxorubicin through elevating KPNA2 expression and activating the PI3K/AKT pathway via adsorbing miR-582-5p.2
365834842023MiR-101-3p targets KPNA2 to inhibit the progression of lung squamous cell carcinoma cell lines.2
371211482023Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma.1
374239522023ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling.1
382833602023Mutational analysis of SARS-CoV-2 ORF6-KPNA2 binding interface and identification of potent small molecule inhibitors to recuse the host immune system.0
347733352022Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.7

Citation

Dessen P

KPNA2 (karyopherin subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41097/kpna2