LAMA4 (laminin subunit alpha 4)

2003-06-01  

Identity

HGNC
LAMA4
LOCATION
6q21
LOCUSID
3910
ALIAS
CMD1JJ,LAMA3,LAMA4*-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3910
MIM: 600133
HGNC: 6484
Ensembl: ENSG00000112769

Variants:

dbSNP: 3910
ClinVar: 3910
TCGA: ENSG00000112769
COSMIC: LAMA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112769ENST00000230538A0A0A0MQS9
ENSG00000112769ENST00000243219E5RFD7
ENSG00000112769ENST00000368638Q16363
ENSG00000112769ENST00000368640H0Y351
ENSG00000112769ENST00000389463A0A0A0MTC7
ENSG00000112769ENST00000424408A0A0A0MTC7
ENSG00000112769ENST00000431543Q6LET9
ENSG00000112769ENST00000453937Q16363
ENSG00000112769ENST00000455073Q16363
ENSG00000112769ENST00000519932E5RHF3
ENSG00000112769ENST00000521398E5RFQ2
ENSG00000112769ENST00000521690E5RK79
ENSG00000112769ENST00000521732H0YAQ5
ENSG00000112769ENST00000522006A0A0A0MTC7
ENSG00000112769ENST00000523765H0YAP9
ENSG00000112769ENST00000651529A0A494C1K8
ENSG00000112769ENST00000651860A0A494C139

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
ECM proteoglycansREACTOMER-HSA-3000178
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368611612023[Research Progress on the Role of Laminin Subunit Alpha 4 in Diseases].1
368611612023[Research Progress on the Role of Laminin Subunit Alpha 4 in Diseases].1
343940032021Laminin-α4 Is Upregulated in Both Human and Murine Models of Obesity.6
344142382021Effect of LAMA4 on Prognosis and Its Correlation with Immune Infiltration in Gastric Cancer.6
343940032021Laminin-α4 Is Upregulated in Both Human and Murine Models of Obesity.6
344142382021Effect of LAMA4 on Prognosis and Its Correlation with Immune Infiltration in Gastric Cancer.6
326284872020Laminin Subunit Alpha-4 and Osteopontin Are Glioblastoma-Selective Secreted Proteins That Are Increased in the Cerebrospinal Fluid of Glioblastoma Patients.3
326284872020Laminin Subunit Alpha-4 and Osteopontin Are Glioblastoma-Selective Secreted Proteins That Are Increased in the Cerebrospinal Fluid of Glioblastoma Patients.3
313435752019Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.21
315536622019Laminin α4 contributes to airway remodeling and inflammation in asthma.8
318422022019Role of LAMA4 Gene in Regulating Extravillous Trophoblasts in Pathogenesis of Preeclampsia.3
313435752019Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.21
315536622019Laminin α4 contributes to airway remodeling and inflammation in asthma.8
318422022019Role of LAMA4 Gene in Regulating Extravillous Trophoblasts in Pathogenesis of Preeclampsia.3
300158612018LAMA4 expression is activated by zinc finger E‑box‑binding homeobox 1 and independently predicts poor overall survival in gastric cancer.11

Citation

Dessen P

LAMA4 (laminin subunit alpha 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41114