LANCL1 (LanC like 1)

2003-02-01  

Identity

HGNC
LANCL1
LOCATION
2q34
LOCUSID
10314
ALIAS
GPR69A,p40
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10314
MIM: 604155
HGNC: 6508
Ensembl: ENSG00000115365

Variants:

dbSNP: 10314
ClinVar: 10314
TCGA: ENSG00000115365
COSMIC: LANCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115365ENST00000233714O43813
ENSG00000115365ENST00000233714Q53TN2
ENSG00000115365ENST00000412863H7C2E3
ENSG00000115365ENST00000431941O43813
ENSG00000115365ENST00000431941Q53TN2
ENSG00000115365ENST00000441020O43813
ENSG00000115365ENST00000441020Q53TN2
ENSG00000115365ENST00000443314O43813
ENSG00000115365ENST00000443314Q53TN2
ENSG00000115365ENST00000448951E9PHS0
ENSG00000115365ENST00000450366O43813
ENSG00000115365ENST00000450366Q53TN2
ENSG00000115365ENST00000453956F8WDS9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375401882024LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.0
375401882024LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.0
368349002023The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure.2
368349002023The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure.2
340981442021LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway.17
340981442021LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway.17
330493342020Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes.1
330493342020Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes.1
294160012018LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway.17
300751992018LanCL1 attenuates ischemia-induced oxidative stress by Sirt3-mediated preservation of mitochondrial function.13
294160012018LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway.17
300751992018LanCL1 attenuates ischemia-induced oxidative stress by Sirt3-mediated preservation of mitochondrial function.13
228912452012Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.19
228912452012Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.19
195283162009Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione.34

Citation

Dessen P

LANCL1 (LanC like 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41125