LDB1 (LIM domain binding 1)
2006-11-01 Takeshi Setogawa , Testu Akiyama AffiliationLaboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Identity
HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
CLIM-2,CLIM2,LDB-1,NLI
FUSION GENES
DNA/RNA
Description
7kb; 11exons
Transcription
2292 nucleotides mRNA
Proteins
Description
375 amino acids; 42.8 kDa protein
Expression
Widely expressed
Localisation
Nuclear
Function
LDB1 is a nuclear protein that contains an N-terminal dimerization domain and a C-terminal LIM interaction domain (LID). LDB1 binds to LIM-homeodomain (LIM-HD) and LIM-only (LMO) proteins. It acts as an adaptor protein that mediates interactions between different classes of transcription factors and their cofactors. LDB1 forms a complex with LKB1, LMO4, and GATA-6. The tumor suppressor LKB1is mutated in Peutz Jeghers syndrome and various sporadic cancers. A complex containing LDB1, LKB1, LMO4, and GATA-6 induces cyclin-dependent kinase inhibitor p21 expression. Targeted deletion of the Ldb1 gene in mice displays multiple developmental defects that reveal a requirement of Ldb1 gene during normal development.
Implicated in
Entity name
Oral squamous cell carcinoma
Oncogenesis
LDB1 and LMO4 are frequently detected in less-differentiated and metastasized squamous carcinoma, and overexpressed at the carcinoma invasive front.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8918878 | 1996 | Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. | Agulnick AD et al |
| 9192866 | 1997 | A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. | Bach I et al |
| 12381786 | 2002 | Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. | Chen L et al |
| 9315627 | 1997 | Functional analysis of the nuclear LIM domain interactor NLI. | Jurata LW et al |
| 14647207 | 2003 | LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. | Matthews JM et al |
| 12771919 | 2003 | The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity. | Mizunuma H et al |
| 12490556 | 2003 | Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. | Mukhopadhyay M et al |
| 16580634 | 2006 | The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1. | Setogawa T et al |
| 9391090 | 1997 | The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. | Visvader JE et al |
Other Information
Locus ID:
NCBI: 8861
MIM: 603451
HGNC: 6532
Ensembl: ENSG00000198728
Variants:
dbSNP: 8861
ClinVar: 8861
TCGA: ENSG00000198728
COSMIC: LDB1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198728 | ENST00000361198 | Q86U70 |
| ENSG00000198728 | ENST00000425280 | Q86U70 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transcriptional misregulation in cancer | KEGG | ko05202 |
| Transcriptional misregulation in cancer | KEGG | hsa05202 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38695236 | 2024 | An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation. | 0 |
| 38695236 | 2024 | An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation. | 0 |
| 37573405 | 2023 | LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1. | 0 |
| 37573405 | 2023 | LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1. | 0 |
| 35881062 | 2022 | The Ldb1 transcriptional co-regulator is required for establishment and maintenance of the pancreatic endocrine lineage. | 2 |
| 35881062 | 2022 | The Ldb1 transcriptional co-regulator is required for establishment and maintenance of the pancreatic endocrine lineage. | 2 |
| 31892537 | 2020 | Crystal structure of human LDB1 in complex with SSBP2. | 13 |
| 32229578 | 2020 | LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia. | 8 |
| 31892537 | 2020 | Crystal structure of human LDB1 in complex with SSBP2. | 13 |
| 32229578 | 2020 | LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia. | 8 |
| 27941246 | 2017 | LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. | 40 |
| 27941246 | 2017 | LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. | 40 |
| 26598604 | 2016 | LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding. | 7 |
| 27713177 | 2016 | LDB1 overexpression is a negative prognostic factor in colorectal cancer. | 11 |
| 26598604 | 2016 | LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding. | 7 |
Citation
Takeshi Setogawa ; Testu Akiyama
LDB1 (LIM domain binding 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-11-01
Online version: http://atlasgeneticsoncology.org/gene/41135/ldb1
