LDHA (lactate dehydrogenase A)

2003-08-01  

Identity

HGNC
LDHA
LOCATION
11p15.1
LOCUSID
3939
ALIAS
GSD11,HEL-S-133P,LDHM,PIG19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3939
MIM: 150000
HGNC: 6535
Ensembl: ENSG00000134333

Variants:

dbSNP: 3939
ClinVar: 3939
TCGA: ENSG00000134333
COSMIC: LDHA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134333ENST00000227157P00338
ENSG00000134333ENST00000379412P00338
ENSG00000134333ENST00000379412V9HWB9
ENSG00000134333ENST00000396222P00338
ENSG00000134333ENST00000422447P00338
ENSG00000134333ENST00000422447V9HWB9
ENSG00000134333ENST00000430553P00338
ENSG00000134333ENST00000478970F5GYU2
ENSG00000134333ENST00000486690F5GWW2
ENSG00000134333ENST00000495052F5GXH2
ENSG00000134333ENST00000535451F5GZQ4
ENSG00000134333ENST00000536528F5GXC7
ENSG00000134333ENST00000539814F5H6W8
ENSG00000134333ENST00000540430P00338
ENSG00000134333ENST00000541097F5H5J4
ENSG00000134333ENST00000542179P00338
ENSG00000134333ENST00000542179V9HWB9
ENSG00000134333ENST00000543445F5GXY2
ENSG00000134333ENST00000543695F5GXU1
ENSG00000134333ENST00000545215F5GWW2
ENSG00000134333ENST00000545467F5H8H6
ENSG00000134333ENST00000625635F5GXU1

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pyruvate metabolismKEGGko00620
Propanoate metabolismKEGGko00640
Glycolysis / GluconeogenesisKEGGhsa00010
Pyruvate metabolismKEGGhsa00620
Propanoate metabolismKEGGhsa00640
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
HIF-1 signaling pathwayKEGGhsa04066
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371612842024LncRNA DLEU2 contributes to Taxol resistance of gastric cancer cells through regulating the miR-30c-5p-LDHA axis.1
377332672024Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex.3
380002332024Identifying the critical oncogenic mechanism of LDHA based on a prognostic model of T-cell synthetic drivers.1
381605382024Single-cell sequencing of the retina shows that LDHA regulates pathogenesis of autoimmune uveitis.2
381638742024Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma.1
382363322024Lactate dehydrogenase A promotes nasopharyngeal carcinoma progression through the TAK1/NF-κB Axis.0
383071562024The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.1
383724492024LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m(6) A modification in triple-negative breast cancer.0
384265792024Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.0
384433362024Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression.4
385140682024HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma.0
387954162024HK2 and LDHA upregulation mediate hexavalent chromium-induced carcinogenesis, cancer development and prognosis through miR-218 inhibition.0
389053162024KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation.0
371612842024LncRNA DLEU2 contributes to Taxol resistance of gastric cancer cells through regulating the miR-30c-5p-LDHA axis.1
377332672024Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex.3

Citation

Dessen P

LDHA (lactate dehydrogenase A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41136/ldha-(lactate-dehydrogenase-a)