LHX3 (LIM homeobox 3)

2003-02-01  

Identity

HGNC
LHX3
LOCATION
9q34.3
LOCUSID
8022
ALIAS
CPHD3,LIM3,M2-LHX3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8022
MIM: 600577
HGNC: 6595
Ensembl: ENSG00000107187

Variants:

dbSNP: 8022
ClinVar: 8022
TCGA: ENSG00000107187
COSMIC: LHX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107187ENST00000371746Q9UBR4
ENSG00000107187ENST00000371746F1T0D9
ENSG00000107187ENST00000371748Q9UBR4
ENSG00000107187ENST00000371748F1T0D5
ENSG00000107187ENST00000619587F1T0D7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
327836532020Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.18
327836532020Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.18
313061022019LHX3 is an advanced-stage prognostic biomarker and metastatic oncogene in hepatocellular carcinoma.7
313061022019LHX3 is an advanced-stage prognostic biomarker and metastatic oncogene in hepatocellular carcinoma.7
287311742017LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma.3
287340202017Molecular analysis of brazilian patients with combined pituitary hormone deficiency and orthotopic posterior pituitary lobe reveals eight different PROP1 alterations with three novel mutations.7
287311742017LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma.3
287340202017Molecular analysis of brazilian patients with combined pituitary hormone deficiency and orthotopic posterior pituitary lobe reveals eight different PROP1 alterations with three novel mutations.7
253992962015Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma.2
255007902015Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.16
253992962015Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma.2
255007902015Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.16
237661282013A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription.16
241002132013Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development.5
237661282013A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription.16

Citation

Dessen P

LHX3 (LIM homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41151