LRP1 (LDL receptor related protein 1)

2003-11-01  

Identity

HGNC
LRP1
LOCATION
12q13.3
LOCUSID
4035
ALIAS
A2MR,APOER,APR,CD91,IGFBP-3R,IGFBP3R,IGFBP3R1,KPA,LRP,LRP1A,TGFBR5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4035
MIM: 107770
HGNC: 6692
Ensembl: ENSG00000123384

Variants:

dbSNP: 4035
ClinVar: 4035
TCGA: ENSG00000123384
COSMIC: LRP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123384ENST00000243077Q07954
ENSG00000123384ENST00000338962Q07954
ENSG00000123384ENST00000553277Q7Z7K9
ENSG00000123384ENST00000554118H0YJI8
ENSG00000123384ENST00000554174Q6PJ72
ENSG00000123384ENST00000555124H0YJ88

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
MalariaKEGGko05144
MalariaKEGGhsa05144
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA150595617platinumChemicalLiteraturenot associated24643204

References

Pubmed IDYearTitleCitations
382785262024A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation.1
382796792024Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins.0
384881242024Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation.0
382785262024A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation.1
382796792024Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins.0
384881242024Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation.0
366086912023LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens.4
368426072023Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell.5
368807312023Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.2
370360052023LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4.3
370607292023Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation.3
370721842023Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.5
371077052023Contribution of LRP1 in Human Congenital Heart Disease Correlates with Its Roles in the Outflow Tract and Atrioventricular Cushion Development.0
373055572023Exome-wide analysis reveals role of LRP1 and additional novel loci in cognition.1
373100252023Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer.1

Citation

Dessen P

LRP1 (LDL receptor related protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41199