LTK (leukocyte receptor tyrosine kinase)

2003-02-01  

Identity

HGNC
LTK
LOCATION
15q15.1
LOCUSID
4058
ALIAS
TYK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4058
MIM: 151520
HGNC: 6721
Ensembl: ENSG00000062524

Variants:

dbSNP: 4058
ClinVar: 4058
TCGA: ENSG00000062524
COSMIC: LTK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000062524ENST00000263800P29376
ENSG00000062524ENST00000355166P29376
ENSG00000062524ENST00000453182P29376
ENSG00000062524ENST00000561619H3BVG6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
385171062024Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.0
385171062024Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.0
346460122021Structural basis of cytokine-mediated activation of ALK family receptors.17
348196632021The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.29
346460122021Structural basis of cytokine-mediated activation of ALK family receptors.17
348196632021The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.29
312275932019LTK is an ER-resident receptor tyrosine kinase that regulates secretion.22
312275932019LTK is an ER-resident receptor tyrosine kinase that regulates secretion.22
266300102015Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.0
266300102015Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.0
253318932014Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.30
253318932014Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.30
223475062012ALK-activating homologous mutations in LTK induce cellular transformation.19
223475062012ALK-activating homologous mutations in LTK induce cellular transformation.19
146953572004Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.14

Citation

Dessen P

LTK (leukocyte receptor tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41218