LY6E (lymphocyte antigen 6 family member E)

2003-11-01  

Identity

HGNC
LY6E
LOCATION
8q24.3
LOCUSID
4061
ALIAS
RIG-E,RIGE,SCA-2,SCA2,TSA-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4061
MIM: 601384
HGNC: 6727
Ensembl: ENSG00000160932

Variants:

dbSNP: 4061
ClinVar: 4061
TCGA: ENSG00000160932
COSMIC: LY6E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160932ENST00000292494Q16553
ENSG00000160932ENST00000429120Q16553
ENSG00000160932ENST00000517503E7EWF8
ENSG00000160932ENST00000519546E5RI33
ENSG00000160932ENST00000519611E5RI33
ENSG00000160932ENST00000520466Q16553
ENSG00000160932ENST00000520531E5RGI6
ENSG00000160932ENST00000521003Q16553
ENSG00000160932ENST00000521182E5RI58
ENSG00000160932ENST00000521699Q16553
ENSG00000160932ENST00000522024Q16553
ENSG00000160932ENST00000522528E5RI58
ENSG00000160932ENST00000522971Q16553
ENSG00000160932ENST00000523847E5RIQ1

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

References

Pubmed IDYearTitleCitations
349943892022α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer.8
353106072022Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer.4
361651902022LY6E protein facilitates adeno-associated virus crossing in a biomimetic chip model of the human blood-brain barrier.2
349943892022α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer.8
353106072022Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer.4
361651902022LY6E protein facilitates adeno-associated virus crossing in a biomimetic chip model of the human blood-brain barrier.2
326941572020A Phase I Study of DLYE5953A, an Anti-LY6E Antibody Covalently Linked to Monomethyl Auristatin E, in Patients with Refractory Solid Tumors.7
328399482020Protein LY6E as a candidate for mediating transport of adeno-associated virus across the human blood-brain barrier.5
326941572020A Phase I Study of DLYE5953A, an Anti-LY6E Antibody Covalently Linked to Monomethyl Auristatin E, in Patients with Refractory Solid Tumors.7
328399482020Protein LY6E as a candidate for mediating transport of adeno-associated virus across the human blood-brain barrier.5
306746302019CD4-Dependent Modulation of HIV-1 Entry by LY6E.16
306746302019CD4-Dependent Modulation of HIV-1 Entry by LY6E.16
294482502018Overexpression of Lymphocyte Antigen 6 Complex, Locus E in Gastric Cancer Promotes Cancer Cell Growth and Metastasis.18
301904772018LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step.69
294482502018Overexpression of Lymphocyte Antigen 6 Complex, Locus E in Gastric Cancer Promotes Cancer Cell Growth and Metastasis.18

Citation

Dessen P

LY6E (lymphocyte antigen 6 family member E)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41220/favicon/gene-explorer/js/_common.js