FEZ1 (fasciculation and elongation protein zeta 1)

2004-05-01 Affiliation

Identity

HGNC

FEZ1

LOCATION

11q24.2

LOCUSID

9638

ALIAS

UNC-76

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9638
MIM: 604825
HGNC: 3659
Ensembl: ENSG00000149557

Variants:

dbSNP: 9638
ClinVar: 9638
TCGA: ENSG00000149557
COSMIC: FEZ1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149557	ENST00000278919	Q99689
ENSG00000149557	ENST00000366139	Q99689
ENSG00000149557	ENST00000524435	Q99689
ENSG00000149557	ENST00000527534	E9PNH2
ENSG00000149557	ENST00000577924	J3KTR6
ENSG00000149557	ENST00000648911	Q99689

Expression (GTEx)

100

200

300

400

500

600

700

800

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37219433	2023	FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression.	1
37219433	2023	FEZ1 Plays Dual Roles in Early HIV-1 Infection by Independently Regulating Capsid Transport and Host Interferon-Stimulated Gene Expression.	1
35172151	2022	FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression.	5
35172151	2022	FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression.	5
33395696	2021	Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.	5
33395696	2021	Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.	5
32590821	2020	Plasma lncRNA FEZF1-AS1 as a potential biomarker for diagnosis of non-small-cell lung carcinoma.	4
32590821	2020	Plasma lncRNA FEZF1-AS1 as a potential biomarker for diagnosis of non-small-cell lung carcinoma.	4
31422020	2019	FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.	42
31422020	2019	FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.	42
25818806	2015	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	82
25818806	2015	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	82
24098481	2013	Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation.	4
24116125	2013	Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO).	4
24098481	2013	Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation.	4

Citation

Dessen P

FEZ1 (fasciculation and elongation protein zeta 1)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/41222/tumors-explorer/