SMAD5 (SMAD family member 5)

2003-02-01  

Identity

HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
DWFC,JV5-1,MADH5
FUSION GENES

Other Information

Locus ID:

NCBI: 4090
MIM: 603110
HGNC: 6771
Ensembl: ENSG00000113658

Variants:

dbSNP: 4090
ClinVar: 4090
TCGA: ENSG00000113658
COSMIC: SMAD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113658ENST00000506223D6R9D4
ENSG00000113658ENST00000507118D6RIZ9
ENSG00000113658ENST00000507637H0YAK7
ENSG00000113658ENST00000509297Q99717
ENSG00000113658ENST00000509297Q68DB7
ENSG00000113658ENST00000511116D6RBB4
ENSG00000113658ENST00000513418H0YAM3
ENSG00000113658ENST00000545279Q99717
ENSG00000113658ENST00000545279Q68DB7
ENSG00000113658ENST00000545620Q99717
ENSG00000113658ENST00000545620Q68DB7

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
BMP signalingKEGGhsa_M00679
BMP signalingKEGGM00679
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382463282024Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.1
387030292024Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.0
382463282024Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.1
387030292024Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.0
372725982023Dysregulation of MicroRNA-152-3p is Associated with the Pathogenesis of Pulpitis by Modulating SMAD5.0
376742522023Circ_0001825 promotes osteogenic differentiation in human-derived mesenchymal stem cells via miR-1270/SMAD5 axis.2
372725982023Dysregulation of MicroRNA-152-3p is Associated with the Pathogenesis of Pulpitis by Modulating SMAD5.0
376742522023Circ_0001825 promotes osteogenic differentiation in human-derived mesenchymal stem cells via miR-1270/SMAD5 axis.2
349748062022Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p.1
349784642022Role of lncRNA LINC01194 in hepatocellular carcinoma via the miR-655-3p/SMAD family member 5 axis.6
349748062022Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p.1
349784642022Role of lncRNA LINC01194 in hepatocellular carcinoma via the miR-655-3p/SMAD family member 5 axis.6
328835382021Long non-coding RNA LINC01116 accelerates the progression of keloid formation by regulating miR-203/SMAD5 axis.8
333717782021Silencing of long non-coding RNA HCP5 inhibits proliferation, invasion, migration, and promotes apoptosis via regulation of miR-299-3p/SMAD5 axis in gastric cancer cells.23
373039382021Long noncoding RNA TMEM147-AS1 serves as a microRNA-326 sponge to aggravate the malignancy of gastric cancer by upregulating SMAD5.1

Citation

Dessen P

SMAD5 (SMAD family member 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41230/smad5