MAFK (MAF bZIP transcription factor K)

2003-11-01  

Identity

HGNC
MAFK
LOCATION
7p22.3
LOCUSID
7975
ALIAS
NFE2U,P18
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7975
MIM: 600197
HGNC: 6782
Ensembl: ENSG00000198517

Variants:

dbSNP: 7975
ClinVar: 7975
TCGA: ENSG00000198517
COSMIC: MAFK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198517ENST00000343242O60675
ENSG00000198517ENST00000343242A0A024R804
ENSG00000198517ENST00000403150O60675
ENSG00000198517ENST00000403150A0A024R804
ENSG00000198517ENST00000406174O60675
ENSG00000198517ENST00000406174A0A024R804

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA166119041drug-induced liver injuryDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006
PA450112isoniazidChemicalClinicalAnnotationassociatedPD22341855, 29036176

References

Pubmed IDYearTitleCitations
352605302022MafK accelerates Salmonella mucosal infection through caspase-3 activation.2
352605302022MafK accelerates Salmonella mucosal infection through caspase-3 activation.2
338778942021MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa.0
338778942021MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa.0
284005382017The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.40
288394362017Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan.2
284005382017The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.40
288394362017Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan.2
262144102015Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation.8
262144102015Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation.8
237375272013Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.28
242320972013Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.27
242477322013MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation.29
237375272013Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.28
242320972013Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.27

Citation

Dessen P

MAFK (MAF bZIP transcription factor K)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41239/cancer-prone-explorer/css/lib/meetings/