MAP2K5 (mitogen-activated protein kinase kinase 5)

2003-11-01  

Identity

HGNC
MAP2K5
LOCATION
15q23
LOCUSID
5607
ALIAS
HsT17454,MAPKK5,MEK5,PRKMK5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5607
MIM: 602520
HGNC: 6845
Ensembl: ENSG00000137764

Variants:

dbSNP: 5607
ClinVar: 5607
TCGA: ENSG00000137764
COSMIC: MAP2K5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137764ENST00000178640Q13163
ENSG00000137764ENST00000178640A0A024R5Y2
ENSG00000137764ENST00000340972A6NK28
ENSG00000137764ENST00000354498Q13163
ENSG00000137764ENST00000395476Q13163
ENSG00000137764ENST00000395476A0A024R5X5
ENSG00000137764ENST00000439036H7BZL1
ENSG00000137764ENST00000557869A0A087X0Z8
ENSG00000137764ENST00000559262A0A087WWX7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Gap junctionKEGGko04540
MAPK signaling pathwayKEGGhsa04010
Gap junctionKEGGhsa04540
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
MAPK (ERK5) signalingKEGGhsa_M00690
MAPK (ERK5) signalingKEGGM00690
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERK5REACTOMER-HSA-198765
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated20124951
PA30616MAPK1GenePathwayassociated20124951
PA30617MAPK10GenePathwayassociated20124951
PA30618MAPK11GenePathwayassociated20124951
PA30619MAPK12GenePathwayassociated20124951
PA30620MAPK13GenePathwayassociated20124951
PA30621MAPK14GenePathwayassociated20124951
PA30622MAPK3GenePathwayassociated20124951
PA30623MAPK4GenePathwayassociated20124951
PA30624MAPK6GenePathwayassociated20124951
PA30625MAPK7GenePathwayassociated20124951
PA30630MAPK9GenePathwayassociated20124951
PA34183RAF1GenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
369682222023MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells.2
372785622023Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival.1
369682222023MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells.2
372785622023Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival.1
357137052022Aberrant MEK5 signalling promotes clear cell renal cell carcinoma development via mTOR activation.0
357137052022Aberrant MEK5 signalling promotes clear cell renal cell carcinoma development via mTOR activation.0
342458542021Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis.8
346819172021The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells.10
342458542021Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis.8
346819172021The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells.10
319693752020The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer.36
332325972020Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults.0
319693752020The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer.36
332325972020Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults.0
301328332019Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non-medullary thyroid carcinoma.18

Citation

Dessen P

MAP2K5 (mitogen-activated protein kinase kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41273/js/lib/teaching-explorer/cancer-prone-explorer/js/lib/bootstrap.min.js