Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4296
MIM: 600050
HGNC: 6850
Ensembl: ENSG00000173327
Variants:
dbSNP: 4296
ClinVar: 4296
TCGA: ENSG00000173327
COSMIC: MAP3K11
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA30588 | MAP2K3 | Gene | Pathway | associated | 23922006 | ||
| PA30591 | MAP2K6 | Gene | Pathway | associated | 23922006 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38858590 | 2024 | MLK3 promotes prooncogenic signaling in hepatocellular carcinoma via TGFβ pathway. | 0 |
| 38858590 | 2024 | MLK3 promotes prooncogenic signaling in hepatocellular carcinoma via TGFβ pathway. | 0 |
| 37550525 | 2023 | MLK3 localizes mainly to the cytoplasm and promotes oxidative stress injury via a positive feedback loop. | 0 |
| 37550525 | 2023 | MLK3 localizes mainly to the cytoplasm and promotes oxidative stress injury via a positive feedback loop. | 0 |
| 35307409 | 2022 | Mechanisms underlying melanoma invasion as a consequence of MLK3 loss. | 0 |
| 35843311 | 2022 | Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division. | 0 |
| 36038020 | 2022 | The role of mixed lineage kinase 3 (MLK3) in cancers. | 1 |
| 36103355 | 2022 | MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma. | 3 |
| 36142785 | 2022 | MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells. | 2 |
| 35307409 | 2022 | Mechanisms underlying melanoma invasion as a consequence of MLK3 loss. | 0 |
| 35843311 | 2022 | Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division. | 0 |
| 36038020 | 2022 | The role of mixed lineage kinase 3 (MLK3) in cancers. | 1 |
| 36103355 | 2022 | MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma. | 3 |
| 36142785 | 2022 | MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells. | 2 |
| 33875576 | 2021 | LATS1 Regulates Mixed-Lineage Kinase 3 (MLK3) Subcellular Localization and MLK3-Mediated Invasion in Ovarian Epithelial Cells. | 2 |
Citation
Dessen P
MAP3K11 (mitogen-activated protein kinase kinase kinase 11)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41277/map3k11
