MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

2003-11-01  

Identity

HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
MAPKKK3,MEKK3
FUSION GENES

Other Information

Locus ID:

NCBI: 4215
MIM: 602539
HGNC: 6855
Ensembl: ENSG00000198909

Variants:

dbSNP: 4215
ClinVar: 4215
TCGA: ENSG00000198909
COSMIC: MAP3K3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198909ENST00000361357Q99759
ENSG00000198909ENST00000361733Q99759
ENSG00000198909ENST00000577395J3KRN4
ENSG00000198909ENST00000577597J3KTC4
ENSG00000198909ENST00000579585Q99759
ENSG00000198909ENST00000581732J3QS19
ENSG00000198909ENST00000584573J3QRB6
ENSG00000198909ENST00000585302J3QS54

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
GnRH signaling pathwayKEGGko04912
MAPK signaling pathwayKEGGhsa04010
GnRH signaling pathwayKEGGhsa04912
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (ERK5) signalingKEGGhsa_M00690
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689
MAPK (ERK5) signalingKEGGM00690
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376584012023Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations.0
376584012023Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations.0
337294802021Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.34
338122502021MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling.3
338918572021Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation.33
341899972021Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis.11
337294802021Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.34
338122502021MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling.3
338918572021Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation.33
341899972021Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis.11
306286632019miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells.14
306520732019MiR-194 regulates nasopharyngeal carcinoma progression by modulating MAP3K3 expression.12
308968202019MicroRNA‑9 suppresses human prostate cancer cell viability, invasion and migration via modulation of mitogen‑activated protein kinase kinase kinase 3 expression.2
311827392019Overexpression of MAP3K3 promotes tumour growth through activation of the NF-κB signalling pathway in ovarian carcinoma.10
306286632019miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells.14

Citation

Dessen P

MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41280/gene-explorer/js/lib/deep-insight-explorer/