MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

2003-11-01  

Identity

HGNC
MAP3K3
LOCATION
17q23.3
LOCUSID
4215
ALIAS
MAPKKK3,MEKK3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4215
MIM: 602539
HGNC: 6855
Ensembl: ENSG00000198909

Variants:

dbSNP: 4215
ClinVar: 4215
TCGA: ENSG00000198909
COSMIC: MAP3K3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198909ENST00000361357Q99759
ENSG00000198909ENST00000361733Q99759
ENSG00000198909ENST00000577395J3KRN4
ENSG00000198909ENST00000577597J3KTC4
ENSG00000198909ENST00000579585Q99759
ENSG00000198909ENST00000581732J3QS19
ENSG00000198909ENST00000584573J3QRB6
ENSG00000198909ENST00000585302J3QS54

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
GnRH signaling pathwayKEGGko04912
MAPK signaling pathwayKEGGhsa04010
GnRH signaling pathwayKEGGhsa04912
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (ERK5) signalingKEGGhsa_M00690
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689
MAPK (ERK5) signalingKEGGM00690
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376584012023Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations.0
376584012023Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations.0
337294802021Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.34
338122502021MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling.3
338918572021Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation.33
341899972021Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis.11
337294802021Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.34
338122502021MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling.3
338918572021Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation.33
341899972021Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis.11
306286632019miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells.14
306520732019MiR-194 regulates nasopharyngeal carcinoma progression by modulating MAP3K3 expression.12
308968202019MicroRNA‑9 suppresses human prostate cancer cell viability, invasion and migration via modulation of mitogen‑activated protein kinase kinase kinase 3 expression.2
311827392019Overexpression of MAP3K3 promotes tumour growth through activation of the NF-κB signalling pathway in ovarian carcinoma.10
306286632019miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells.14

Citation

Dessen P

MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41280/img/gene-fusions/css/template-card.css