MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

2003-11-01  

Identity

HGNC
MAP4K4
LOCATION
2q11.2
LOCUSID
9448
ALIAS
FLH21957,HEL-S-31,HGK,MEKKK4,NIK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9448
MIM: 604666
HGNC: 6866
Ensembl: ENSG00000071054

Variants:

dbSNP: 9448
ClinVar: 9448
TCGA: ENSG00000071054
COSMIC: MAP4K4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071054ENST00000302217C9J840
ENSG00000071054ENST00000324219G5E948
ENSG00000071054ENST00000347699O95819
ENSG00000071054ENST00000350198G3XAA2
ENSG00000071054ENST00000413150E7ENQ1
ENSG00000071054ENST00000417294H7C360
ENSG00000071054ENST00000418101H7C3Z6
ENSG00000071054ENST00000421882H7C0P6
ENSG00000071054ENST00000425019E7EN19
ENSG00000071054ENST00000427603E7ETN6
ENSG00000071054ENST00000456652E7EX83
ENSG00000071054ENST00000625522A0A0D9SEY1
ENSG00000071054ENST00000627726A0A0D9SG62

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA448432anastrozoleChemicalClinicalAnnotationassociatedPD
PA449563exemestaneChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
383838422024MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.0
386433332024FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.0
386798772024Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies.0
387249872024MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1.1
383838422024MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.0
386433332024FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.0
386798772024Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies.0
387249872024MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1.1
364691372023Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association.3
369226782023MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage.5
371265462023Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.0
373127102023Evaluation of the Role of MAP4K4 in Focal Adhesion Dynamics and Regulation of Cell Migration of Breast Cancer Cell Line MDA-MB-231.0
374425292023CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p.1
364691372023Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association.3
369226782023MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage.5

Citation

Dessen P

MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41287