MEP1B (meprin A subunit beta)

2003-10-01  

Identity

HGNC
MEP1B
LOCATION
18q12.1
LOCUSID
4225
ALIAS
-

Other Information

Locus ID:

NCBI: 4225
MIM: 600389
HGNC: 7020
Ensembl: ENSG00000141434

Variants:

dbSNP: 4225
ClinVar: 4225
TCGA: ENSG00000141434
COSMIC: MEP1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141434ENST00000269202Q16820
ENSG00000141434ENST00000581184J3KRK1
ENSG00000141434ENST00000581447J3QKX5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369763992023The putative pleiotropic functions of meprin β in gastric cancer.0
369763992023The putative pleiotropic functions of meprin β in gastric cancer.0
340733502021Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor.2
340733502021Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor.2
310765142019The cancer-associated meprin β variant G32R provides an additional activation site and promotes cancer cell invasion.7
316048202019Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β.0
310765142019The cancer-associated meprin β variant G32R provides an additional activation site and promotes cancer cell invasion.7
316048202019Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β.0
280591122017Meprin β contributes to collagen deposition in lung fibrosis.17
283650012017Meprin β and BMP-1 are differentially regulated by CaCl(2).1
285025932017Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis.19
291666022017Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.16
280591122017Meprin β contributes to collagen deposition in lung fibrosis.17
283650012017Meprin β and BMP-1 are differentially regulated by CaCl(2).1
285025932017Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis.19

Citation

Dessen P

MEP1B (meprin A subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/41336