MEPE (matrix extracellular phosphoglycoprotein)

2003-02-01  

Identity

HGNC
MEPE
LOCATION
4q22.1
LOCUSID
56955
ALIAS
OF45

Other Information

Locus ID:

NCBI: 56955
MIM: 605912
HGNC: 13361
Ensembl: ENSG00000152595

Variants:

dbSNP: 56955
ClinVar: 56955
TCGA: ENSG00000152595
COSMIC: MEPE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152595ENST00000361056Q9NQ76
ENSG00000152595ENST00000361056A0A024RDD1
ENSG00000152595ENST00000395102Q9NQ76
ENSG00000152595ENST00000424957Q9NQ76
ENSG00000152595ENST00000424957A0A024RDD1
ENSG00000152595ENST00000497649D6RAC8
ENSG00000152595ENST00000511670D6RFW6
ENSG00000152595ENST00000540395Q9NQ76
ENSG00000152595ENST00000560249Q9NQ76

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
327123872020Active sites of human MEPE-ASARM regulating bone matrix mineralization.1
330977032020MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk.13
327123872020Active sites of human MEPE-ASARM regulating bone matrix mineralization.1
330977032020MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk.13
302879252019Variants affecting diverse domains of MEPE are associated with two distinct bone disorders, a craniofacial bone defect and otosclerosis.9
302879252019Variants affecting diverse domains of MEPE are associated with two distinct bone disorders, a craniofacial bone defect and otosclerosis.9
235703702013MicroRNA-376a sensitizes cells following DNA damage by downregulating MEPE expression.6
235703702013MicroRNA-376a sensitizes cells following DNA damage by downregulating MEPE expression.6
217390892012Matrix extracellular phosphoglycoprotein is expressed in causative tumors of oncogenic osteomalacia.17
223410702012The effect of matrix extracellular phosphoglycoprotein and its downstream osteogenesis-related gene expression on the proliferation and differentiation of human dental pulp cells.8
217390892012Matrix extracellular phosphoglycoprotein is expressed in causative tumors of oncogenic osteomalacia.17
223410702012The effect of matrix extracellular phosphoglycoprotein and its downstream osteogenesis-related gene expression on the proliferation and differentiation of human dental pulp cells.8
213122672011Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.88
217793812011Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.6
213122672011Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.88

Citation

Dessen P

MEPE (matrix extracellular phosphoglycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41337