FGF4 (fibroblast growth factor 4)

2003-02-01 Affiliation

Identity

HGNC

FGF4

LOCATION

11q13.3

LOCUSID

2249

ALIAS

FGF-4,HBGF-4,HST,HST-1,HSTF-1,HSTF1,K-FGF,KFGF

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2249
MIM: 164980
HGNC: 3682
Ensembl: ENSG00000075388

Variants:

dbSNP: 2249
ClinVar: 2249
TCGA: ENSG00000075388
COSMIC: FGF4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000075388	ENST00000168712	P08620

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Regulation of actin cytoskeleton	KEGG	ko04810
Melanoma	KEGG	ko05218
MAPK signaling pathway	KEGG	hsa04010
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Melanoma	KEGG	hsa05218
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR1 in disease	REACTOME	R-HSA-5655302
FGFR1 mutant receptor activation	REACTOME	R-HSA-1839124
Signaling by activated point mutants of FGFR1	REACTOME	R-HSA-1839122
Signaling by FGFR2 in disease	REACTOME	R-HSA-5655253
FGFR2 mutant receptor activation	REACTOME	R-HSA-1839126
Activated point mutants of FGFR2	REACTOME	R-HSA-2033519
Signaling by FGFR3 in disease	REACTOME	R-HSA-5655332
FGFR3 mutant receptor activation	REACTOME	R-HSA-2033514
Signaling by activated point mutants of FGFR3	REACTOME	R-HSA-1839130
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR1	REACTOME	R-HSA-5654736
FGFR1 ligand binding and activation	REACTOME	R-HSA-190242
FGFR1c ligand binding and activation	REACTOME	R-HSA-190373
Downstream signaling of activated FGFR1	REACTOME	R-HSA-5654687
FRS-mediated FGFR1 signaling	REACTOME	R-HSA-5654693
Phospholipase C-mediated cascade: FGFR1	REACTOME	R-HSA-5654219
SHC-mediated cascade:FGFR1	REACTOME	R-HSA-5654688
PI-3K cascade:FGFR1	REACTOME	R-HSA-5654689
Negative regulation of FGFR1 signaling	REACTOME	R-HSA-5654726
Signaling by FGFR2	REACTOME	R-HSA-5654738
FGFR2 ligand binding and activation	REACTOME	R-HSA-190241
FGFR2c ligand binding and activation	REACTOME	R-HSA-190375
Downstream signaling of activated FGFR2	REACTOME	R-HSA-5654696
FRS-mediated FGFR2 signaling	REACTOME	R-HSA-5654700
Phospholipase C-mediated cascade; FGFR2	REACTOME	R-HSA-5654221
SHC-mediated cascade:FGFR2	REACTOME	R-HSA-5654699
PI-3K cascade:FGFR2	REACTOME	R-HSA-5654695
Negative regulation of FGFR2 signaling	REACTOME	R-HSA-5654727
Signaling by FGFR3	REACTOME	R-HSA-5654741
FGFR3 ligand binding and activation	REACTOME	R-HSA-190239
FGFR3c ligand binding and activation	REACTOME	R-HSA-190372
Downstream signaling of activated FGFR3	REACTOME	R-HSA-5654708
FRS-mediated FGFR3 signaling	REACTOME	R-HSA-5654706
Phospholipase C-mediated cascade; FGFR3	REACTOME	R-HSA-5654227
SHC-mediated cascade:FGFR3	REACTOME	R-HSA-5654704
PI-3K cascade:FGFR3	REACTOME	R-HSA-5654710
Negative regulation of FGFR3 signaling	REACTOME	R-HSA-5654732
Signaling by FGFR4	REACTOME	R-HSA-5654743
FGFR4 ligand binding and activation	REACTOME	R-HSA-190322
Downstream signaling of activated FGFR4	REACTOME	R-HSA-5654716
FRS-mediated FGFR4 signaling	REACTOME	R-HSA-5654712
Phospholipase C-mediated cascade; FGFR4	REACTOME	R-HSA-5654228
SHC-mediated cascade:FGFR4	REACTOME	R-HSA-5654719
PI-3K cascade:FGFR4	REACTOME	R-HSA-5654720
Negative regulation of FGFR4 signaling	REACTOME	R-HSA-5654733
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
FGFRL1 modulation of FGFR1 signaling	REACTOME	R-HSA-5658623
Signaling by FGFR3 point mutants in cancer	REACTOME	R-HSA-8853338
RET signaling	REACTOME	R-HSA-8853659
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36521556	2023	FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of Slug.	1
36702076	2023	FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.	7
36521556	2023	FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of Slug.	1
36702076	2023	FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.	7
32023352	2020	miR-511 inhibits proliferation and metastasis of breast cancer cells by targeting FGF4.	4
33199729	2020	Gene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST.	6
32023352	2020	miR-511 inhibits proliferation and metastasis of breast cancer cells by targeting FGF4.	4
33199729	2020	Gene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST.	6
28378614	2018	Association of Fibroblast Growth Factor Receptor 4 Genetic Polymorphisms With the Development of Uterine Cervical Cancer and Patient Prognosis.	8
29936056	2018	Poor prognostic impact of FGF4 amplification in patients with esophageal squamous cell carcinoma.	4
28378614	2018	Association of Fibroblast Growth Factor Receptor 4 Genetic Polymorphisms With the Development of Uterine Cervical Cancer and Patient Prognosis.	8
29936056	2018	Poor prognostic impact of FGF4 amplification in patients with esophageal squamous cell carcinoma.	4
26828265	2016	The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.	15
26828265	2016	The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.	15
24120895	2014	Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.	7

Citation

Dessen P

FGF4 (fibroblast growth factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/414/meetings/gene-explorer/deep-insight-explorer/