Identity
HGNC
LOCATION
10q24.1
LOCUSID
ALIAS
CIAO4,MET18,MMS19L,hMMS19
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64210
MIM: 614777
HGNC: 13824
Ensembl: ENSG00000155229
Variants:
dbSNP: 64210
ClinVar: 64210
TCGA: ENSG00000155229
COSMIC: MMS19
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Cytosolic iron-sulfur cluster assembly | REACTOME | R-HSA-2564830 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37201439 | 2023 | The c-MYC transcription factor conduces to resistance to cisplatin by regulating MMS19 in bladder cancer cells. | 1 |
| 37201439 | 2023 | The c-MYC transcription factor conduces to resistance to cisplatin by regulating MMS19 in bladder cancer cells. | 1 |
| 32632277 | 2020 | Structural insights into Fe-S protein biogenesis by the CIA targeting complex. | 10 |
| 32632277 | 2020 | Structural insights into Fe-S protein biogenesis by the CIA targeting complex. | 10 |
| 29035693 | 2018 | MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage. | 3 |
| 29035693 | 2018 | MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage. | 3 |
| 27235625 | 2016 | Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. | 4 |
| 27802208 | 2016 | MMS19 as a potential predictive marker of adjuvant chemotherapy benefit in resected non-small cell lung cancer. | 3 |
| 27235625 | 2016 | Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. | 4 |
| 27802208 | 2016 | MMS19 as a potential predictive marker of adjuvant chemotherapy benefit in resected non-small cell lung cancer. | 3 |
| 25892874 | 2015 | Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer. | 6 |
| 25892874 | 2015 | Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer. | 6 |
| 23585563 | 2013 | IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway. | 16 |
| 23632208 | 2013 | The role of single nucleotide polymorphisms of the ERCC1 and MMS19 genes in predicting platinum-sensitivity, progression-free and overall survival in advanced epithelial ovarian cancer. | 7 |
| 23679317 | 2013 | Single nucleotide polymorphisms in the NER pathway and clinical outcome of patients with bone malignant tumors. | 9 |
Citation
Dessen P
MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component)
Atlas Genet Cytogenet Oncol Haematol. 2004-04-01
Online version: http://atlasgeneticsoncology.org/gene/41410/mms19
