MPG (N-methylpurine DNA glycosylase)

2003-02-01  

Identity

HGNC
MPG
LOCATION
16p13.3
LOCUSID
4350
ALIAS
AAG,ADPG,APNG,CRA36.1,MDG,Mid1,PIG11,PIG16,anpg
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4350
MIM: 156565
HGNC: 7211
Ensembl: ENSG00000103152

Variants:

dbSNP: 4350
ClinVar: 4350
TCGA: ENSG00000103152
COSMIC: MPG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103152ENST00000219431P29372
ENSG00000103152ENST00000219431Q1W6H1
ENSG00000103152ENST00000356432P29372
ENSG00000103152ENST00000397817P29372
ENSG00000103152ENST00000436333A2IDA3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepurinationREACTOMER-HSA-73927
Recognition and association of DNA glycosylase with site containing an affected purineREACTOMER-HSA-110330
Cleavage of the damaged purineREACTOMER-HSA-110331
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Displacement of DNA glycosylase by APEX1REACTOMER-HSA-110357

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
383325762024Transformed astrocytes confer temozolomide resistance on glioblastoma via delivering ALKBH7 to enhance APNG expression after educating by glioblastoma stem cells-derived exosomes.1
383325762024Transformed astrocytes confer temozolomide resistance on glioblastoma via delivering ALKBH7 to enhance APNG expression after educating by glioblastoma stem cells-derived exosomes.1
338099072021Pilot Study to Detect Genes Involved in DNA Damage and Cancer in Humans: Potential Biomarkers of Exposure to E-Cigarette Aerosols.8
338099072021Pilot Study to Detect Genes Involved in DNA Damage and Cancer in Humans: Potential Biomarkers of Exposure to E-Cigarette Aerosols.8
318825382020Recognition of 1,N(2)-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active-site residue.2
318825382020Recognition of 1,N(2)-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active-site residue.2
317845302019Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.16
317845302019Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.16
299400972018Distinguishing Specific and Nonspecific Complexes of Alkyladenine DNA Glycosylase.4
302410462018PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway.5
299400972018Distinguishing Specific and Nonspecific Complexes of Alkyladenine DNA Glycosylase.4
302410462018PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway.5
285752362017Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.17
286620732017APNG as a prognostic marker in patients with glioblastoma.8
287474352017Search for DNA damage by human alkyladenine DNA glycosylase involves early intercalation by an aromatic residue.5

Citation

Dessen P

MPG (N-methylpurine DNA glycosylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41418/img/gene-explorer/