Identity
HGNC
LOCATION
3q22.3
LOCUSID
ALIAS
M-RAs,NS11,R-RAS3,RRAS3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22808
MIM: 608435
HGNC: 7227
Ensembl: ENSG00000158186
Variants:
dbSNP: 22808
ClinVar: 22808
TCGA: ENSG00000158186
COSMIC: MRAS
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24928 | ARAF | Gene | Pathway | associated | |||
| PA25408 | BRAF | Gene | Pathway | associated | |||
| PA30592 | MAP3K1 | Gene | Pathway | associated | |||
| PA34183 | RAF1 | Gene | Pathway | associated | |||
| PA7360 | EGFR | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37277529 | 2023 | Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS. | 17 |
| 37277529 | 2023 | Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS. | 17 |
| 35768504 | 2022 | Structural basis for SHOC2 modulation of RAS signalling. | 8 |
| 35830882 | 2022 | Structure of the MRAS-SHOC2-PP1C phosphatase complex. | 7 |
| 35831509 | 2022 | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. | 19 |
| 36175670 | 2022 | Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. | 11 |
| 35768504 | 2022 | Structural basis for SHOC2 modulation of RAS signalling. | 8 |
| 35830882 | 2022 | Structure of the MRAS-SHOC2-PP1C phosphatase complex. | 7 |
| 35831509 | 2022 | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. | 19 |
| 36175670 | 2022 | Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. | 11 |
| 34080768 | 2021 | Atypical, severe hypertrophic cardiomyopathy in a newborn presenting Noonan syndrome harboring a recurrent heterozygous MRAS variant. | 4 |
| 34080768 | 2021 | Atypical, severe hypertrophic cardiomyopathy in a newborn presenting Noonan syndrome harboring a recurrent heterozygous MRAS variant. | 4 |
| 31108500 | 2020 | Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy. | 21 |
| 32495899 | 2020 | Correlation between MRAS gene polymorphism and atherosclerosis. | 1 |
| 31108500 | 2020 | Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy. | 21 |
Citation
Dessen P
MRAS (muscle RAS oncogene homolog)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41425/mras
