MSLN (mesothelin)

2003-06-01  

Identity

HGNC
MSLN
LOCATION
16p13.3
LOCUSID
10232
ALIAS
MPF,SMRP

Other Information

Locus ID:

NCBI: 10232
MIM: 601051
HGNC: 7371
Ensembl: ENSG00000102854

Variants:

dbSNP: 10232
ClinVar: 10232
TCGA: ENSG00000102854
COSMIC: MSLN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102854ENST00000382862Q13421
ENSG00000102854ENST00000545450Q13421
ENSG00000102854ENST00000561896H3BUX1
ENSG00000102854ENST00000563651H3BR90
ENSG00000102854ENST00000563941Q13421
ENSG00000102854ENST00000566269H3BMA1
ENSG00000102854ENST00000566549Q13421
ENSG00000102854ENST00000569566H3BV92

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379145282024Mesothelin expression in gynecologic carcinosarcoma: clinicopathological significance and correlation with HER2 expression.0
382276662024Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope.1
383968172024Enhanced Expression of Glycolytic Enzymes and Succinate Dehydrogenase Complex Flavoprotein Subunit A by Mesothelin Promotes Glycolysis and Mitochondrial Respiration in Myeloblasts of Acute Myeloid Leukemia.0
386378852024Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer.0
379145282024Mesothelin expression in gynecologic carcinosarcoma: clinicopathological significance and correlation with HER2 expression.0
382276662024Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope.1
383968172024Enhanced Expression of Glycolytic Enzymes and Succinate Dehydrogenase Complex Flavoprotein Subunit A by Mesothelin Promotes Glycolysis and Mitochondrial Respiration in Myeloblasts of Acute Myeloid Leukemia.0
386378852024Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer.0
370409002023High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma.4
377750212023Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression.1
370409002023High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma.4
377750212023Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression.1
351629542022Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer.0
353407462022Effects of hsa-mir-145-5p on the Regulation of msln Expression in Colorectal Adenocarcinoma.0
351629542022Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer.0

Citation

Dessen P

MSLN (mesothelin)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41433