MT1A (metallothionein 1A)

2003-08-01  

Identity

HGNC
MT1A
LOCATION
16q13
LOCUSID
4489
ALIAS
MT-1A,MT-IA,MT1,MT1S,MTC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4489
MIM: 156350
HGNC: 7393
Ensembl: ENSG00000205362

Variants:

dbSNP: 4489
ClinVar: 4489
TCGA: ENSG00000205362
COSMIC: MT1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205362ENST00000290705P04731

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
MetabolismREACTOMER-HSA-1430728
Response to metal ionsREACTOMER-HSA-5660526
Metallothioneins bind metalsREACTOMER-HSA-5661231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285527oxaliplatinChemicalLiterature, MultilinkAnnotationassociated24924344
PA448486arsenic trioxideChemicalLiterature, MultilinkAnnotationassociated24924344

References

Pubmed IDYearTitleCitations
384904562024Human apo-metallothionein 1a is not a random coil: Evidence from guanidinium chloride, high temperature, and acidic pH unfolding studies.0
384904562024Human apo-metallothionein 1a is not a random coil: Evidence from guanidinium chloride, high temperature, and acidic pH unfolding studies.0
369810432023An Assessment of MT1A (rs11076161), MT2A (rs28366003) and MT1L (rs10636) Gene Polymorphisms and MT2 Concentration in Women with Endometrial Pathologies.0
369810432023An Assessment of MT1A (rs11076161), MT2A (rs28366003) and MT1L (rs10636) Gene Polymorphisms and MT2 Concentration in Women with Endometrial Pathologies.0
330849772021Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions.3
330849772021Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions.3
320315542020pH dependence of the non-cooperative binding of Bi(3+) to human apo-metallothionein 1A: kinetics, speciation, and stoichiometry.4
323401092020Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers.3
327848152020Interplay between Carbonic Anhydrases and Metallothioneins: Structural Control of Metalation.5
328166512020Effect of metallothionein 1A rs8052394 polymorphism on lead, cadmium, zinc, and aluminum levels in factory workers.1
332253292020The pathways and domain specificity of Cu(I) binding to human metallothionein 1A.7
320315542020pH dependence of the non-cooperative binding of Bi(3+) to human apo-metallothionein 1A: kinetics, speciation, and stoichiometry.4
323401092020Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers.3
327848152020Interplay between Carbonic Anhydrases and Metallothioneins: Structural Control of Metalation.5
328166512020Effect of metallothionein 1A rs8052394 polymorphism on lead, cadmium, zinc, and aluminum levels in factory workers.1

Citation

Dessen P

MT1A (metallothionein 1A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41439