MT3 (metallothionein 3)

2003-08-01  

Identity

HGNC
MT3
LOCATION
16q13
LOCUSID
4504
ALIAS
GIF,GIFB,GRIF,ZnMT3

Other Information

Locus ID:

NCBI: 4504
MIM: 139255
HGNC: 7408
Ensembl: ENSG00000087250

Variants:

dbSNP: 4504
ClinVar: 4504
TCGA: ENSG00000087250
COSMIC: MT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087250ENST00000200691P25713
ENSG00000087250ENST00000200691A0A024R6R7
ENSG00000087250ENST00000561640H3BPK2
ENSG00000087250ENST00000565838H3BQX6
ENSG00000087250ENST00000570176H3BTG5

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Response to metal ionsREACTOMER-HSA-5660526
Metallothioneins bind metalsREACTOMER-HSA-5661231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366390302023Apo-metallothionein-3 cooperatively forms tightly compact structures under physiological conditions.1
366390302023Apo-metallothionein-3 cooperatively forms tightly compact structures under physiological conditions.1
355037712022Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells.0
355037712022Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells.0
335263212021Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa.2
337508142021Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma.13
335263212021Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa.2
337508142021Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma.13
325125762020miR-325-3p Overexpression Inhibits Proliferation and Metastasis of Bladder Cancer Cells by Regulating MT3.2
325125762020miR-325-3p Overexpression Inhibits Proliferation and Metastasis of Bladder Cancer Cells by Regulating MT3.2
308134602019Metallothionein 3 Is a Hypoxia-Upregulated Oncogene Enhancing Cell Invasion and Tumorigenesis in Human Bladder Carcinoma Cells.13
313248672019Multistep Protein Unfolding Scenarios from the Rupture of a Complex Metal Cluster Cd(3)S(9).10
308134602019Metallothionein 3 Is a Hypoxia-Upregulated Oncogene Enhancing Cell Invasion and Tumorigenesis in Human Bladder Carcinoma Cells.13
313248672019Multistep Protein Unfolding Scenarios from the Rupture of a Complex Metal Cluster Cd(3)S(9).10
295241062018Association Study Between Metallothionein-3 Protein Polymorphisms and Autism.1

Citation

Dessen P

MT3 (metallothionein 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41442