NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2)

2003-06-01  

Identity

HGNC
NAALAD2
LOCATION
11q14.3
LOCUSID
10003
ALIAS
GCPIII,GPCIII,NAADALASE2,NAALADASE2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10003
MIM: 611636
HGNC: 14526
Ensembl: ENSG00000077616

Variants:

dbSNP: 10003
ClinVar: 10003
TCGA: ENSG00000077616
COSMIC: NAALAD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077616ENST00000321955J3KNJ3
ENSG00000077616ENST00000375944Q9Y3Q0
ENSG00000077616ENST00000525171E9PKX5
ENSG00000077616ENST00000525497E9PII2
ENSG00000077616ENST00000526637E9PJ53
ENSG00000077616ENST00000527493E9PJV2
ENSG00000077616ENST00000534061Q9Y3Q0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
348508842022Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.1
348508842022Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.1
341987252021Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence.9
341987252021Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence.9
308447042019GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.6
308447042019GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.6
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
119059942002Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.37
122047972002Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.12
119059942002Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II.37
122047972002Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.12

Citation

Dessen P

NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41490/haematological-explorer/tumors-explorer/js/template.js