NACA (nascent polypeptide associated complex subunit alpha)

2004-03-01  

Identity

HGNC
NACA
LOCATION
12q13.3
LOCUSID
4666
ALIAS
HSD48,NAC-alpha,NACA1,skNAC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4666
MIM: 601234
HGNC: 7629
Ensembl: ENSG00000196531

Variants:

dbSNP: 4666
ClinVar: 4666
TCGA: ENSG00000196531
COSMIC: NACA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196531ENST00000356769Q13765
ENSG00000196531ENST00000356769A0A024RB41
ENSG00000196531ENST00000393891Q13765
ENSG00000196531ENST00000393891A0A024RB41
ENSG00000196531ENST00000454682E9PAV3
ENSG00000196531ENST00000546392Q13765
ENSG00000196531ENST00000546392A0A024RB41
ENSG00000196531ENST00000546862F8W1N5
ENSG00000196531ENST00000547914F8W029
ENSG00000196531ENST00000548084F8W0C7
ENSG00000196531ENST00000548563F8VZJ2
ENSG00000196531ENST00000549259F8W0W4
ENSG00000196531ENST00000549855F8VZ58
ENSG00000196531ENST00000550920H0YHX9
ENSG00000196531ENST00000550952E9PAV3
ENSG00000196531ENST00000552055F8VNW4
ENSG00000196531ENST00000552540Q13765
ENSG00000196531ENST00000552540A0A024RB41

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
362195632022The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α.3
362195632022The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α.3
309485082019Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.8
309827452019Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.17
309485082019Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.8
309827452019Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.17
249010532014αNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells.0
252095252014Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading.2
249010532014αNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells.0
252095252014Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading.2
215095942011Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.7
220823602011Combinatorial control of ATF4-dependent gene transcription in osteoblasts.6
215095942011Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.7
220823602011Combinatorial control of ATF4-dependent gene transcription in osteoblasts.6
202143992010The crystal structure of the human nascent polypeptide-associated complex domain reveals a nucleic acid-binding region on the NACA subunit .18

Citation

Dessen P

NACA (nascent polypeptide associated complex subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2004-03-01

Online version: http://atlasgeneticsoncology.org/gene/41491