NBL1 (NBL1, DAN family BMP antagonist)

2003-02-01  

Identity

HGNC
NBL1
LOCATION
1p36.13
LOCUSID
4681
ALIAS
D1S1733E,DAN,DAND1,NB,NO3

Other Information

Locus ID:

NCBI: 4681
MIM: 600613
HGNC: 7650
Ensembl: ENSG00000158747

Variants:

dbSNP: 4681
ClinVar: 4681
TCGA: ENSG00000158747
COSMIC: NBL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158747ENST00000289749P41271
ENSG00000158747ENST00000375136P41271
ENSG00000158747ENST00000425400A3KFI3
ENSG00000158747ENST00000427894E5RFZ1
ENSG00000158747ENST00000428975A3KFI4
ENSG00000158747ENST00000439278A3KFI1
ENSG00000158747ENST00000439664A3KFI2
ENSG00000158747ENST00000451758A3KFI5
ENSG00000158747ENST00000548815P41271
ENSG00000158747ENST00000602662P41271
ENSG00000158747ENST00000615215A0A087WTY6
ENSG00000158747ENST00000618761P41271
ENSG00000158747ENST00000621723P41271
ENSG00000158747ENST00000622566P41271

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
374365742023Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy.1
374365742023Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy.1
359476732022Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes.11
359476732022Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes.11
275246262016Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism.31
275246262016Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism.31
255617252015Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists.21
255617252015Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists.21
248103822014The DAN family: modulators of TGF-β signaling and beyond.38
248103822014The DAN family: modulators of TGF-β signaling and beyond.38
229487492013The search for secreted proteins in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of NBL1 is highly restricted to the prostate and is related to cancer progression.5
229487492013The search for secreted proteins in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of NBL1 is highly restricted to the prostate and is related to cancer progression.5
217439592011Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.11
217439592011Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.11
199957122009NBL1 and anillin (ANLN) genes over-expression in pancreatic carcinoma.33

Citation

Dessen P

NBL1 (NBL1, DAN family BMP antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41501