NEDD8 (NEDD8 ubiquitin like modifier)

2003-08-01  

Identity

HGNC
NEDD8
LOCATION
14q12
LOCUSID
4738
ALIAS
NEDD-8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4738
MIM: 603171
HGNC: 7732
Ensembl: ENSG00000129559

Variants:

dbSNP: 4738
ClinVar: 4738
TCGA: ENSG00000129559
COSMIC: NEDD8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129559ENST00000250495Q15843
ENSG00000129559ENST00000396828F8VSA6
ENSG00000129559ENST00000524927F8VSA6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383910332024Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).0
386780242024Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.0
383910332024Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).0
386780242024Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.0
379054842023[Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].0
379054842023[Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].0
347168662022Blocking neddylation elicits antiviral effect against hepatitis B virus replication.2
347168662022Blocking neddylation elicits antiviral effect against hepatitis B virus replication.2
332684652021The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.9
332889572021Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.18
334203602021TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.15
334720762021Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.28
339660472021Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.2
341564622021The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.1
346423282021Structural and functional consequences of NEDD8 phosphorylation.9

Citation

Dessen P

NEDD8 (NEDD8 ubiquitin like modifier)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41518/js/lib/tumors-explorer/case-report-explorer/