Identity
HGNC
LOCATION
3p21.1
LOCUSID
ALIAS
NRK2,STK2,pp12301
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6787
MIM: 601959
HGNC: 11399
Ensembl: ENSG00000114904
Variants:
dbSNP: 6787
ClinVar: 6787
TCGA: ENSG00000114904
COSMIC: NEK4
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31743747 | 2020 | Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling. | 12 |
| 31743747 | 2020 | Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling. | 12 |
| 30247800 | 2018 | NEK4 kinase regulates EMT to promote lung cancer metastasis. | 16 |
| 30247800 | 2018 | NEK4 kinase regulates EMT to promote lung cancer metastasis. | 16 |
| 27602754 | 2016 | Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death. | 0 |
| 27602754 | 2016 | Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death. | 0 |
| 22851694 | 2012 | Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. | 32 |
| 22851694 | 2012 | Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. | 32 |
| 21685204 | 2011 | The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. | 41 |
| 21685204 | 2011 | The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. | 41 |
| 20103636 | 2010 | Nek4 status differentially alters sensitivity to distinct microtubule poisons. | 20 |
| 20734064 | 2010 | A large-scale candidate gene association study of age at menarche and age at natural menopause. | 57 |
| 20800603 | 2010 | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. | 14 |
| 20103636 | 2010 | Nek4 status differentially alters sensitivity to distinct microtubule poisons. | 20 |
| 20734064 | 2010 | A large-scale candidate gene association study of age at menarche and age at natural menopause. | 57 |
Citation
Dessen P
NEK4 (NIMA related kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41522/nek4
