Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4825
MIM: 602563
HGNC: 7839
Ensembl: ENSG00000163623
Variants:
dbSNP: 4825
ClinVar: 4825
TCGA: ENSG00000163623
COSMIC: NKX6-1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000163623 | ENST00000295886 | P78426 |
| ENSG00000163623 | ENST00000515820 | F8VWZ9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35256556 | 2022 | NKX6-1 Is a Less Sensitive But Specific Biomarker of Chromophobe Renal Cell Carcinoma. | 0 |
| 35256556 | 2022 | NKX6-1 Is a Less Sensitive But Specific Biomarker of Chromophobe Renal Cell Carcinoma. | 0 |
| 32862769 | 2021 | MiR-190b impedes pancreatic β cell proliferation and insulin secretion by targeting NKX6-1 and may associate to gestational diabetes mellitus. | 3 |
| 33906647 | 2021 | NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma. | 8 |
| 34493754 | 2021 | Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects. | 4 |
| 32862769 | 2021 | MiR-190b impedes pancreatic β cell proliferation and insulin secretion by targeting NKX6-1 and may associate to gestational diabetes mellitus. | 3 |
| 33906647 | 2021 | NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma. | 8 |
| 34493754 | 2021 | Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects. | 4 |
| 32707737 | 2020 | NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer. | 9 |
| 33121533 | 2020 | NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation. | 40 |
| 32707737 | 2020 | NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer. | 9 |
| 33121533 | 2020 | NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation. | 40 |
| 29363224 | 2018 | NKX6.1 hypermethylation predicts the outcome of stage II colorectal cancer patients undergoing chemotherapy. | 11 |
| 30284410 | 2018 | Immunohistochemical analysis of OTP and NKX6.1 in neuroendocrine tumors of the lung and pancreas. | 4 |
| 29363224 | 2018 | NKX6.1 hypermethylation predicts the outcome of stage II colorectal cancer patients undergoing chemotherapy. | 11 |
Citation
Dessen P
NKX6-1 (NK6 homeobox 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41542/nkx6-1
