Identity
HGNC
LOCATION
17q21.33
LOCUSID
ALIAS
NDKB,NDPK-B,NDPKB,NM23-H2,NM23B,PUF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4831
MIM: 156491
HGNC: 7850
Ensembl: ENSG00000243678
Variants:
dbSNP: 4831
ClinVar: 4831
TCGA: ENSG00000243678
COSMIC: NME2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10005 | adefovir dipivoxil | Chemical | Pathway | associated | |||
| PA10204 | tenofovir | Chemical | Pathway | associated | |||
| PA450163 | lamivudine | Chemical | Pathway | associated | |||
| PA451954 | zidovudine | Chemical | Pathway | associated | 22960662 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35259022 | 2022 | Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis. | 10 |
| 35259022 | 2022 | Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis. | 10 |
| 34628473 | 2021 | Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells. | 9 |
| 34628473 | 2021 | Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells. | 9 |
| 31694930 | 2020 | NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors. | 10 |
| 32392889 | 2020 | The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis. | 18 |
| 32492501 | 2020 | Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. | 1 |
| 33086728 | 2020 | Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity. | 8 |
| 31694930 | 2020 | NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors. | 10 |
| 32392889 | 2020 | The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis. | 18 |
| 32492501 | 2020 | Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. | 1 |
| 33086728 | 2020 | Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity. | 8 |
| 29251738 | 2018 | NM23 proteins: innocent bystanders or local energy boosters for CFTR? | 1 |
| 29475390 | 2018 | Nucleoside diphosphate kinase 2 confers acquired 5-fluorouracil resistance in colorectal cancer cells. | 10 |
| 29630434 | 2018 | Nucleoside diphosphate kinase B promotes osteosarcoma proliferation through c-Myc. | 7 |
Citation
Dessen P
NME2 (NME/NM23 nucleoside diphosphate kinase 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41544/nme2
