Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4878
MIM: 108780
HGNC: 7939
Ensembl: ENSG00000175206
Variants:
dbSNP: 4878
ClinVar: 4878
TCGA: ENSG00000175206
COSMIC: NPPA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000175206 | ENST00000376476 | B0ZBE8 |
| ENSG00000175206 | ENST00000376480 | P01160 |
| ENSG00000175206 | ENST00000610706 | A0A087X094 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166128188 | systolic blood pressure | Disease | VariantAnnotation | associated | PD | 18212314 | |
| PA443635 | Cardiovascular Diseases | Disease | ClinicalAnnotation | associated | PD | 18212314 | |
| PA443797 | Coronary Disease | Disease | ClinicalAnnotation | associated | PD | 18212314 | |
| PA444552 | Hypertension | Disease | VariantAnnotation | associated | PD | 18212314 | |
| PA447054 | Stroke | Disease | ClinicalAnnotation | associated | PD | 18212314 | |
| PA448388 | amlodipine | Chemical | ClinicalAnnotation | associated | PD | 18212314 | |
| PA448970 | chlorthalidone | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 18212314 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36336901 | 2023 | Regulatory role of atrial natriuretic peptide in brown adipose tissue: A narrative review. | 0 |
| 37099206 | 2023 | Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure. | 6 |
| 37417873 | 2023 | Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population. | 2 |
| 37913506 | 2023 | Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis. | 2 |
| 36336901 | 2023 | Regulatory role of atrial natriuretic peptide in brown adipose tissue: A narrative review. | 0 |
| 37099206 | 2023 | Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure. | 6 |
| 37417873 | 2023 | Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population. | 2 |
| 37913506 | 2023 | Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis. | 2 |
| 34875662 | 2022 | NPPA Promoter Hypomethylation Predicts Central Obesity Development: A Prospective Longitudinal Study in Chinese Adults. | 0 |
| 35393944 | 2022 | Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model. | 11 |
| 35586748 | 2022 | Serum Atrial Natriuretic Peptide, NPPA Promoter Methylation, and Cardiovascular Disease: A 10-year Follow-Up Study in Chinese Adults. | 1 |
| 34875662 | 2022 | NPPA Promoter Hypomethylation Predicts Central Obesity Development: A Prospective Longitudinal Study in Chinese Adults. | 0 |
| 35393944 | 2022 | Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model. | 11 |
| 35586748 | 2022 | Serum Atrial Natriuretic Peptide, NPPA Promoter Methylation, and Cardiovascular Disease: A 10-year Follow-Up Study in Chinese Adults. | 1 |
| 32861716 | 2021 | T2238C atrial natriuretic peptide gene variant and cardiovascular events in patients with atrial fibrillation: A substudy from the ATHERO-AF cohort. | 1 |
Citation
Dessen P
NPPA (natriuretic peptide A)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41567/nppa
