NR1H2 (nuclear receptor subfamily 1 group H member 2)

2003-02-01  

Identity

HGNC
NR1H2
LOCATION
19q13.33
LOCUSID
7376
ALIAS
LXR-b,LXRB,NER,NER-I,RIP15,UNR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7376
MIM: 600380
HGNC: 7965
Ensembl: ENSG00000131408

Variants:

dbSNP: 7376
ClinVar: 7376
TCGA: ENSG00000131408
COSMIC: NR1H2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131408ENST00000253727P55055
ENSG00000131408ENST00000593532M0R229
ENSG00000131408ENST00000593926P55055
ENSG00000131408ENST00000597130M0R1V8
ENSG00000131408ENST00000597157M0QYE6
ENSG00000131408ENST00000597790M0QZF5
ENSG00000131408ENST00000598168M0R0K3
ENSG00000131408ENST00000599105M0R2F9
ENSG00000131408ENST00000600355M0R3A7
ENSG00000131408ENST00000652203P55055

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Insulin resistanceKEGGhsa04931
VLDL interactionsREACTOMER-HSA-8855121
VLDLR internalisation and degradationREACTOMER-HSA-8866427

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131301952gefitinibChemicalClinicalAnnotationassociatedPD31664190
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD31664190
PA443899DiarrheaDiseaseClinicalAnnotationassociatedPD31664190

References

Pubmed IDYearTitleCitations
362511372023Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner.1
368024342023Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.2
369303542023Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB.4
362511372023Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner.1
368024342023Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.2
369303542023Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB.4
358107732022CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1.6
358107732022CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1.6
329979752021Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.10
338623682021LXRβ is involved in the control of platelet production from megakaryocytes.0
340850982021Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer.4
341536832021MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.3
329979752021Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.10
338623682021LXRβ is involved in the control of platelet production from megakaryocytes.0
340850982021Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer.4

Citation

Dessen P

NR1H2 (nuclear receptor subfamily 1 group H member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41570