Identity
HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
LXR-b,LXRB,NER,NER-I,RIP15,UNR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7376
MIM: 600380
HGNC: 7965
Ensembl: ENSG00000131408
Variants:
dbSNP: 7376
ClinVar: 7376
TCGA: ENSG00000131408
COSMIC: NR1H2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131301952 | gefitinib | Chemical | ClinicalAnnotation | associated | PD | 31664190 | |
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 31664190 | |
| PA443899 | Diarrhea | Disease | ClinicalAnnotation | associated | PD | 31664190 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36251137 | 2023 | Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner. | 1 |
| 36802434 | 2023 | Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1. | 2 |
| 36930354 | 2023 | Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. | 4 |
| 36251137 | 2023 | Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner. | 1 |
| 36802434 | 2023 | Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1. | 2 |
| 36930354 | 2023 | Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB. | 4 |
| 35810773 | 2022 | CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1. | 6 |
| 35810773 | 2022 | CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1. | 6 |
| 32997975 | 2021 | Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE. | 10 |
| 33862368 | 2021 | LXRβ is involved in the control of platelet production from megakaryocytes. | 0 |
| 34085098 | 2021 | Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer. | 4 |
| 34153683 | 2021 | MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase. | 3 |
| 32997975 | 2021 | Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE. | 10 |
| 33862368 | 2021 | LXRβ is involved in the control of platelet production from megakaryocytes. | 0 |
| 34085098 | 2021 | Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer. | 4 |
Citation
Dessen P
NR1H2 (nuclear receptor subfamily 1 group H member 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41570/nr1h2
