NRP1 (neuropilin 1)

2003-08-01  

Identity

HGNC
NRP1
LOCATION
10p11.22
LOCUSID
8829
ALIAS
BDCA4,CD304,NP1,NRP,VEGF165R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8829
MIM: 602069
HGNC: 8004
Ensembl: ENSG00000099250

Variants:

dbSNP: 8829
ClinVar: 8829
TCGA: ENSG00000099250
COSMIC: NRP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099250ENST00000265371O14786
ENSG00000099250ENST00000374816E7EX60
ENSG00000099250ENST00000374821O14786
ENSG00000099250ENST00000374822O14786
ENSG00000099250ENST00000374823Q5T7F0
ENSG00000099250ENST00000374867O14786
ENSG00000099250ENST00000374875Q5JWQ6
ENSG00000099250ENST00000395995E9PEP6
ENSG00000099250ENST00000413802Q5JWQ2
ENSG00000099250ENST00000418675H0Y7Z2
ENSG00000099250ENST00000431894H0Y4N6
ENSG00000099250ENST00000432372Q5JWQ4
ENSG00000099250ENST00000455749H0Y4A0
ENSG00000099250ENST00000466932V9GYL7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
Neurophilin interactions with VEGF and VEGFRREACTOMER-HSA-194306
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
CRMPs in Sema3A signalingREACTOMER-HSA-399956
L1CAM interactionsREACTOMER-HSA-373760
Signal transduction by L1REACTOMER-HSA-445144
CHL1 interactionsREACTOMER-HSA-447041

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134850558Macular DegenerationDiseaseClinicalAnnotationassociatedPD26426212
PA164746012ranibizumabChemicalClinicalAnnotationassociatedPD26426212
PA30086KDRGenePathwayassociated20124951
PA37302VEGFAGenePathwayassociated20124951
PA37303VEGFBGenePathwayassociated20124951
PA37304VEGFCGenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
375332402024Sema3A Alleviates the Malignant Behaviors of Gastric Cancer Cells by Inhibiting NRP-1.2
378780352024Expression of placental growth factor, neuropilin-1, and neuropilin-2 in primary pterygium tissue.0
379430812024CD304 + adipose tissue-derived mesenchymal stem cell abundance in autologous fat grafts highly correlates with improvement of localized pain syndromes.0
382202122024NRP1 Induces Enhanced Stemness and Chemoresistance in Glioma Cells via YAP.0
383245852024Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.3
386740092024DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2 Infection.0
375332402024Sema3A Alleviates the Malignant Behaviors of Gastric Cancer Cells by Inhibiting NRP-1.2
378780352024Expression of placental growth factor, neuropilin-1, and neuropilin-2 in primary pterygium tissue.0
379430812024CD304 + adipose tissue-derived mesenchymal stem cell abundance in autologous fat grafts highly correlates with improvement of localized pain syndromes.0
382202122024NRP1 Induces Enhanced Stemness and Chemoresistance in Glioma Cells via YAP.0
383245852024Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.3
386740092024DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2 Infection.0
363336302023NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.8
363763732023Hepatocellular carcinoma cells loss lenvatinib efficacy in vitro through autophagy and hypoxia response-derived neuropilin-1 degradation.6
368113962023Targeting neuropilin-1 abolishes anti-PD-1-upregulated regulatory T cells and synergizes with 4-1BB agonist for liver cancer treatment.3

Citation

Dessen P

NRP1 (neuropilin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41582