Identity
HGNC
LOCATION
3p21.1
LOCUSID
ALIAS
C77032,E2IG3,NNP47,NS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26354
MIM: 608011
HGNC: 29931
Ensembl: ENSG00000163938
Variants:
dbSNP: 26354
ClinVar: 26354
TCGA: ENSG00000163938
COSMIC: GNL3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Ribosome biogenesis in eukaryotes | KEGG | ko03008 |
| Ribosome biogenesis in eukaryotes | KEGG | hsa03008 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA445113 | Neutropenia | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | ||
| PA449476 | epirubicin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38970264 | 2024 | Knockdown of GNL3 inhibits LUAD cell growth by regulating Wnt-β-catenin pathway. | 0 |
| 38970264 | 2024 | Knockdown of GNL3 inhibits LUAD cell growth by regulating Wnt-β-catenin pathway. | 0 |
| 37965896 | 2023 | The nucleolar protein GNL3 prevents resection of stalled replication forks. | 1 |
| 37965896 | 2023 | The nucleolar protein GNL3 prevents resection of stalled replication forks. | 1 |
| 34487784 | 2022 | RNA-seq reveal RNA binding protein GNL3 as a key mediator in the development of psoriasis vulgaris by regulating the IL23/IL17 axis. | 3 |
| 35638911 | 2022 | Association of Nucleostemin Polymorphisms with Chronic Hepatitis B Virus Infection in Chinese Han Population. | 0 |
| 35886999 | 2022 | Proteomic Investigation of the Role of Nucleostemin in Nucleophosmin-Mutated OCI-AML 3 Cell Line. | 4 |
| 36167888 | 2022 | Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population. | 2 |
| 34487784 | 2022 | RNA-seq reveal RNA binding protein GNL3 as a key mediator in the development of psoriasis vulgaris by regulating the IL23/IL17 axis. | 3 |
| 35638911 | 2022 | Association of Nucleostemin Polymorphisms with Chronic Hepatitis B Virus Infection in Chinese Han Population. | 0 |
| 35886999 | 2022 | Proteomic Investigation of the Role of Nucleostemin in Nucleophosmin-Mutated OCI-AML 3 Cell Line. | 4 |
| 36167888 | 2022 | Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population. | 2 |
| 33358901 | 2021 | RNA binding protein GNL3 up-regulates IL24 and PTN to promote the development of osteoarthritis. | 7 |
| 34681573 | 2021 | Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry. | 4 |
| 34762898 | 2021 | G protein nucleolar 3 promotes Non-Hodgkin lymphoma progression by activating the Wnt/β-catenin signaling pathway. | 1 |
Citation
Dessen P
GNL3 (G protein nucleolar 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41584/gnl3
