NUDT1 (nudix hydrolase 1)

2003-02-01  

Identity

HGNC
NUDT1
LOCATION
7p22.3
LOCUSID
4521
ALIAS
MTH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4521
MIM: 600312
HGNC: 8048
Ensembl: ENSG00000106268

Variants:

dbSNP: 4521
ClinVar: 4521
TCGA: ENSG00000106268
COSMIC: NUDT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106268ENST00000339737P36639
ENSG00000106268ENST00000339737A0A024R819
ENSG00000106268ENST00000343985P36639
ENSG00000106268ENST00000343985A0A024R858
ENSG00000106268ENST00000356714P36639
ENSG00000106268ENST00000356714A0A024R819
ENSG00000106268ENST00000397046P36639
ENSG00000106268ENST00000397046A0A024R819
ENSG00000106268ENST00000397048P36639
ENSG00000106268ENST00000397048A0A024R858
ENSG00000106268ENST00000397049P36639
ENSG00000106268ENST00000397049A0A024R819
ENSG00000106268ENST00000454650C9J361

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NUDT proteinsREACTOMER-HSA-2393930

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA1661531718-oxo-dgtpChemicalMultilinkAnnotationassociated26238318

References

Pubmed IDYearTitleCitations
361300542023miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1.7
369143752023Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.0
378488552023Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma.2
361300542023miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1.7
369143752023Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.0
378488552023Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma.2
358097672022MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3.1
358097672022MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3.1
330214052021Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.17
330961442021The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.4
331300782021MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha.1
337375762021Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma.3
346244812021Specific 8-oxo-dGTPase activity of MTH1 (NUDT1) protein as a quantitative marker and prognostic factor in human colorectal cancer.4
330214052021Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.17
330961442021The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.4

Citation

Dessen P

NUDT1 (nudix hydrolase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41590/haematological-explorer/gene-explorer/js/web-card-_common.js