Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4255
MIM: 156569
HGNC: 7059
Ensembl: ENSG00000170430
Variants:
dbSNP: 4255
ClinVar: 4255
TCGA: ENSG00000170430
COSMIC: MGMT
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000170430 | ENST00000306010 | B4DEE8 |
| ENSG00000170430 | ENST00000651593 | P16455 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA Repair | REACTOME | R-HSA-73894 |
| DNA Damage Reversal | REACTOME | R-HSA-73942 |
| MGMT-mediated DNA damage reversal | REACTOME | R-HSA-5657655 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA451609 | temozolomide | Chemical | MultilinkAnnotation | associated | 24444404 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37382159 | 2024 | O(6) -methylguanine methyltransferase promoter methylation status of glioblastoma cell line clonal population. | 0 |
| 37641495 | 2024 | Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O(6) -methylguanine-DNA methyltransferase gene in glioblastoma. | 1 |
| 37988281 | 2024 | IDH1-mutated Crohn's disease-associated small bowel adenocarcinomas: Distinctive pathological features and association with MGMT methylation and serrated-type dysplasia. | 0 |
| 38203783 | 2024 | Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma. | 1 |
| 38277015 | 2024 | Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma. | 2 |
| 38288307 | 2024 | Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression. | 0 |
| 38520591 | 2024 | Predominance of MGMT promoter methylation among Pakistani glioblastoma patients. | 0 |
| 38542081 | 2024 | Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women. | 0 |
| 37382159 | 2024 | O(6) -methylguanine methyltransferase promoter methylation status of glioblastoma cell line clonal population. | 0 |
| 37641495 | 2024 | Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O(6) -methylguanine-DNA methyltransferase gene in glioblastoma. | 1 |
| 37988281 | 2024 | IDH1-mutated Crohn's disease-associated small bowel adenocarcinomas: Distinctive pathological features and association with MGMT methylation and serrated-type dysplasia. | 0 |
| 38203783 | 2024 | Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma. | 1 |
| 38277015 | 2024 | Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma. | 2 |
| 38288307 | 2024 | Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression. | 0 |
| 38520591 | 2024 | Predominance of MGMT promoter methylation among Pakistani glioblastoma patients. | 0 |
Citation
Dessen P
MGMT (O-6-methylguanine-DNA methyltransferase)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/416/mgmt
